[1]马晓龙,刘强,吴斗,等.骨转换标志物在骨质疏松诊治中的分析评价及临床应用前景[J].中华老年骨科与康复电子杂志,2018,(01):52-56.[doi:10.3877/cma.j.issn.2096-0263.2018.01.012]
　Ma Xiaolong,Liu Qiang,Wu Dou,et al.Assessment of bone metabolic markers and clinical application prospect in the diagnosis and treatment of osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(01):52-56.[doi:10.3877/cma.j.issn.2096-0263.2018.01.012]
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骨转换标志物在骨质疏松诊治中的分析评价及临床应用前景()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2018年01期
页码:
52-56
栏目:
综述
出版日期:
2018-01-31

文章信息/Info

Title:
Assessment of bone metabolic markers and clinical application prospect in the diagnosis and treatment of osteoporosis
作者:
马晓龙1; 刘强2; 吴斗2; 郑上团1
030001 太原，山西医科大学1；山西大医院骨科2
Author(s):
Ma Xiaolong1;  Liu Qiang2;  Wu Dou2;  Zheng Shangtuan1
1Shanxi Medical University; 2Department of Orthopaedics, Shanxi DaYi Hospital, Taiyuan 030032, China
关键词:
骨生成;  骨吸收;  骨质疏松症;  生物标志物
Keywords:
Osteogenesis;  Bone resorption;  Osteoporosis;  Biomarkers
DOI:
10.3877/cma.j.issn.2096-0263.2018.01.012
文献标志码:
A
摘要:
骨代谢的生化标志物是成骨细胞和破骨细胞活动而释放至血和尿中的骨基质成分，可以反映整体骨转换率，对诊断骨质疏松症及其分型、预测骨量丢失情况、评估完全骨折的危险性、监测药物治疗疗效等均有重要的意义。目前BALP、TRACP、PINP、β-CTX等骨转换标志物已被大量应用于临床，但每种骨转换标志物均有其特殊性及变异性，综合分析才能对骨质疏松的演变及治疗进展有一个较好的评判。本文主要探讨了临床常用的骨转换标志物的应用现状及应用前景。
Abstract:
Biochemical markers of bone metabolism are some bone matrix components generated from osteoblasts and osteoclasts and released into the blood and urine. They are used to reflect the overall rate of bone turnover, and have an important significance in the diagnosis of osteoporosis and classification, prediction of bone loss, assessment of complete fracture risk and monitoring drug efficacy, etc. At present, the bone turnover markers such as BALP, TRACP, PINP, β-CTX etc. have been applied in the clinic extensively. But each bone turnover marker has its particularity and variability. A comprehensive analysis is needed for a better judge of the evolution and treatment of osteoporosis. This article mainly explored the clinical application and perspective of commonly used bone turnover markers.

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　Wu Shilei,Liu Yong,Shao Zengwu,et al. Research status of bone tissue-derived exosomes on bone metabolism[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(01):308.

备注/Memo

备注/Memo:
基金项目：山西省自然科学基金（2013011057-4）
更新日期/Last Update: 2018-01-31