[1]王晨光,张华峰,李稚君,等.Wnt 信号通路在骨折愈合过程中作用与机制的研究进展[J].中华老年骨科与康复电子杂志,2016,(03):189-192.[doi:10.3877/cma.j.issn.2096-0263.2016.03.013]
Wang Chenguang,Zhang Huafeng,Li Zhijun,et al.Effect and mechanism of the Wnt signaling pathway in fracture healing[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2016,(03):189-192.[doi:10.3877/cma.j.issn.2096-0263.2016.03.013]
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Wnt 信号通路在骨折愈合过程中作用与机制的研究进展(
)
中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]
- 卷:
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- 期数:
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2016年03期
- 页码:
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189-192
- 栏目:
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综述
- 出版日期:
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2016-08-05
文章信息/Info
- Title:
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Effect and mechanism of the Wnt signaling pathway in fracture healing
- 作者:
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王晨光; 张华峰; 李稚君; 李晖
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300052 天津医科大学总医院骨科
- Author(s):
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Wang Chenguang; Zhang Huafeng; Li Zhijun; Li Hui
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Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin 300052, China
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- 关键词:
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Wnt 信号通路; 骨折愈合
- Keywords:
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Wnt proteins; Fractures healing
- DOI:
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10.3877/cma.j.issn.2096-0263.2016.03.013
- 文献标志码:
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A
- 摘要:
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Wnt 信号通路在骨折修复过程中对骨骼发育和骨组织内稳态具有重要作用，本文综述了当前 Wnt 信号通路在骨折修复过程中的作用与机制，涉及各种成骨细胞与调节因子的相互作用， Wnt 信号有助于加速骨修复，其抑制剂和中和抗体可能成为骨修复中最有前途的治疗药物，为骨折优化治疗提供参考。
- Abstract:
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In the process of fracture repairing, Wnt signaling pathway plays an important role in bone development and bone tissue homeostasis. We reviewed the current view of Wnt signaling pathway in fracture repairing, involving various interactions and regulation of bone cell activating factors. Wnt signaling contribute to bone repair, the inhibitors and neutralizing antibodies, that might become the most promising medicine and provide references for fracture healing.
备注/Memo
- 备注/Memo:
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基金项目：国家自然科学基金（81501887）
更新日期/Last Update:
2017-04-01