中枢敏化及其对膝关节骨关节炎临床治疗的影响-中华老年骨科与康复电子杂志

文章信息/Info

Title:: Central sensitization and its effect on the clinical treatment of knee osteoarthritis

Author(s):: Zheng Yi; Kang Kai; Wang Zhijie; Wang Juan.; The Second Department of Arthrosis, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Keywords:: Central sensitization; Chronic pain; Osteoarthritis; Knee; Drug?therapy

摘要:: 骨关节炎的疼痛可触发外周痛觉感受器，并在中枢神经系统内进行调节，导致中枢敏化。中枢敏化是膝关节骨关节炎慢性疼痛的一个重要机制。降低中枢痛觉敏化可有效缓解膝关节骨关节炎及全膝关节置换术后的疼痛，减少阿片类药物用量，改善患者预后。本文就中枢敏化的概念、形成机制、临床特点和评估及药物治疗等方面进行综述，以期提高临床医生对中枢敏化的认识和重视，从而给予患者有效治疗。

Abstract:: Osteoarthritis pain triggers peripheral nociceptors and regulates them in the central nervous system, leading to central sensitization, an important mechanism for chronic pain in knee osteoarthritis. Lowering central pain sensitization can effectively alleviate pain caused by knee osteoarthritis and total knee arthroplasty, thus reducing the usage of opioids and improving patient prognosis. This article reviews the concepts of central sensitization, its formation mechanism, clinical characteristics, evaluation, and drug treatment, with a view to improving clinicians’ awareness and emphasis on central sensitization, which will result in more effective treatment.