[1]郑义,康凯,王智杰,等.中枢敏化及其对膝关节骨关节炎临床治疗的影响[J].中华老年骨科与康复电子杂志,2020,(04):243-247.[doi:050051 石家庄， 河北医科大学第三医院关节二科]
　Zheng Yi,Kang Kai,Wang Zhijie,et al.Central sensitization and its effect on the clinical treatment of knee osteoarthritis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2020,(04):243-247.[doi:050051 石家庄， 河北医科大学第三医院关节二科]
点击复制

中枢敏化及其对膝关节骨关节炎临床治疗的影响()
分享到：

中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2020年04期
页码:
243-247
栏目:
综述
出版日期:
2020-08-05

文章信息/Info

Title:
Central sensitization and its effect on the clinical treatment of knee osteoarthritis
作者:
郑义; 康凯; 王智杰; 王娟
050051 石家庄， 河北医科大学第三医院关节二科
Author(s):
Zheng Yi;  Kang Kai;  Wang Zhijie;  Wang Juan.
The Second Department of Arthrosis, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
关键词:
中枢敏化;  慢性疼痛;  骨关节炎; 膝;  药物治疗
Keywords:
Central sensitization;  Chronic pain;  Osteoarthritis;  Knee;  Drug?therapy
DOI:
050051 石家庄， 河北医科大学第三医院关节二科
文献标志码:
A
摘要:
骨关节炎的疼痛可触发外周痛觉感受器，并在中枢神经系统内进行调节，导致中枢敏化。中枢敏化是膝关节骨关节炎慢性疼痛的一个重要机制。降低中枢痛觉敏化可有效缓解膝关节骨关节炎及全膝关节置换术后的疼痛，减少阿片类药物用量，改善患者预后。本文就中枢敏化的概念、形成机制、临床特点和评估及药物治疗等方面进行综述，以期提高临床医生对中枢敏化的认识和重视，从而给予患者有效治疗。
Abstract:
Osteoarthritis pain triggers peripheral nociceptors and regulates them in the central nervous system, leading to central sensitization, an important mechanism for chronic pain in knee osteoarthritis. Lowering central pain sensitization can effectively alleviate pain caused by knee osteoarthritis and total knee arthroplasty, thus reducing the usage of opioids and improving patient prognosis. This article reviews the concepts of central sensitization, its formation mechanism, clinical characteristics, evaluation, and drug treatment, with a view to improving clinicians’ awareness and emphasis on central sensitization, which will result in more effective treatment.

相似文献/References:

[1]荣锦 骆明星 王禹 刘婷婷 张宏斌.全膝关节置换术后慢性疼痛影响因素的多种模型预测性能比较[J].中华老年骨科与康复电子杂志,2025,(06):337.[doi:10.3877/cma.j.issn.2096-0263.2025.06.003]
　Rong Jin,Luo Mingxing,Wang Yu,et al.Comparison of predictive performance of multiple models of factors affecting chronic pain after total knee arthroplasty[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2025,(04):337.[doi:10.3877/cma.j.issn.2096-0263.2025.06.003]

备注/Memo

备注/Memo:
基金项目：中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助（2019PT320001）；国家自然科学基金委（91949203）
更新日期/Last Update: 2020-08-18