[1]文学,孙红,王洪,等.PTHrP类似物阿巴洛肽在骨质疏松症中的研究进展[J].中华老年骨科与康复电子杂志,2021,(02):117-121.[doi:10.3877/cma.j.issn.2096-0263.2021.02.009]
　Wen Xue,Sun Hong,Wang Hong,et al.Research progress of PTHrP analogue abaloparide in osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2021,(02):117-121.[doi:10.3877/cma.j.issn.2096-0263.2021.02.009]
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PTHrP类似物阿巴洛肽在骨质疏松症中的研究进展()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2021年02期
页码:
117-121
栏目:
综述
出版日期:
2021-04-05

文章信息/Info

Title:
Research progress of PTHrP analogue abaloparide in osteoporosis
作者:
文学1; 孙红2; 王洪2; 刘淼2; 宁旭2
550004 贵阳，贵州医科大学1；550004 贵阳，贵州医科大学附属医院骨科2
Author(s):
Wen Xue1;  Sun Hong2;  Wang Hong2;  Liu Miao2;  Ning Xu2.
1Guizhou Medical University, Guiyang 550004, China; 2Department of Orthopaedics, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
关键词:
骨质疏松症;  PTHrP类似物;  阿巴洛肽;  特立帕肽;  综述文献
Keywords:
Osteoporosis;  PTHrP analog;  Abaloparatide;  Teriparatide;  Literature review
DOI:
10.3877/cma.j.issn.2096-0263.2021.02.009
文献标志码:
A
摘要:
阿巴洛肽是人类甲状旁腺激素相关蛋白（PTHrP）的氨基酸合成类似物，是一种新型的甲状旁腺激素1受体信号通路的选择性激活剂，可增加骨密度和骨量，改善骨微结构和强度，是继特立帕肽后第二种骨合成药物。PTHrP类似物可通过提高骨量，促进骨合成。许多临床前研究及基础研究发现阿巴洛肽对于治疗绝经后骨质疏松疗效确切，为治疗绝经后骨质疏松症提供了新的治疗策略，但仍需大量及大型动物研究以更好的验证PTHrP类似物用于治疗骨质疏松症的生物安全性。本文就骨合成药物PTHrP类似物阿巴洛肽在骨质疏松症患者的研究进展作一综述。
Abstract:
Abaloparatide, the amino acid synthesis analogue of human parathyroid hormone-related protein (PTHrP), is a novel selective activator of the parathyroid hormone-1 receptor signaling pathway, which can increase bone density and bone mass, improve bone microstructure and strength, and is the second bone synthesis drug after Teriptide.Many preclinical and basic studies have found that abaloparatide is effective in the treatment of postmenopausal osteoporosis, providing a new treatment strategy for postmenopausal osteoporosis, but a large number of studies and large animal studies are still needed to better verify the biosafsafety of PTHrP analogue in the treatment of osteoporosis. This article reviews the progress in the study of the bone synthesis drug PTHrP analogue abaloparatide in patients with osteoporosis.

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备注/Memo

备注/Memo:
基金项目：贵州省卫生健康委科学技术基金项目（gzwjkj2019-1-134；gzwjkj2020-1-120）
更新日期/Last Update: 2021-05-10