[1]伦登兴,徐丽娜,李思影,等.酸碱调节对硫酸钙骨水泥理化性能影响的体外研究[J].中华老年骨科与康复电子杂志,2024,(03):125-131.[doi:DOI：10.3877/cma.j.issn.2096-0263.2024.03.001]
　Lun Dengxing,Xu Lina,Li Siying,et al.In vitro study on the effect of acid-base regulation on the physicochemical properties of calcium sulfate bone cement[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2024,(03):125-131.[doi:DOI：10.3877/cma.j.issn.2096-0263.2024.03.001]
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酸碱调节对硫酸钙骨水泥理化性能影响的体外研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2024年03期
页码:
125-131
栏目:
论著
出版日期:
2024-06-05

文章信息/Info

Title:
In vitro study on the effect of acid-base regulation on the physicochemical properties of calcium sulfate bone cement
作者:
伦登兴1; 徐丽娜2; 李思影1; 李世龙1; 张伟航1; 胡永成3
261041 潍坊市人民医院（山东第二医科大学第一附属医院）骨肿瘤科1，呼吸与危重症医学科2；300211 天津市天津医院骨与软组织肿瘤科3
Author(s):
Lun Dengxing1;  Xu Lina2;  Li Siying1;  Li Shilong1;  Zhang Weihang1;  Hu Yongcheng3
1Department of Bone Oncology, 2Department of Respiratory and Critical Care Medicine, Weifang People’s Hospital (the First Affiliated Hospital of Shandong Second Medical University), Weifang 261041, China; 3Department of Bone and Soft Tissue Oncology, Tianjin hospital, Tianjin 300211, China
关键词:
碳酸钙;  硫酸钙;  骨水泥成形术;  抗压强度;  凝固时间
Keywords:
Calcium carbonate;  Calcium sulfate;  Cementoplasty;  Compressive strength;  Setting time
DOI:
DOI：10.3877/cma.j.issn.2096-0263.2024.03.001
文献标志码:
A
摘要:
目的 探讨碱性碳酸钙对硫酸钙骨水泥的理化性能的影响，为制备适合酸碱度的、可注射性硫酸钙骨水泥提供理论依据。方法 按CaCO3在硫酸钙复合物的质量比，分为0%、5%、10%、20%、30%组共5组。充分混合不同含量与外科级硫酸钙制备骨水泥的粉剂。将浓度为3%的甲基纤维素溶液作为骨水泥的液剂。按液固比0.4∶1，混合上述骨水泥的粉剂和液剂，搅拌均匀，形成浆体。根据不同的模具，测量并记录CaCO3/硫酸钙复合物的初凝时间、终凝时间、抗压强度、体外降解率及pH值变化。结果 单纯硫酸钙的初凝时间和终凝时间分别为（4.96±0.20）、（5.83±0.12）min。随着CaCO3的含量的增加，初凝时间和终凝时间呈先增长后降低的趋势（F=25.428、P＜0.001；F=30.780、P＜0.001）。当含量为10%时初凝时间和终凝时间最长[（13.17±1.87）min和（14.22±2.00）min]。单纯硫酸钙的抗压强度为（23.33±6.35）MPa。随CaCO3的含量的增加，抗压强度先增强后降低，当含量为20%，抗压强度最大（27.33±5.86）MPa；但CaCO3对硫酸钙抗压强度的影响无统计学差异（F=1.272，P=0.344）。单纯硫酸钙在降解过程均呈酸性环境（pH=5.32），不同含量碳酸钙均能提高pH值；且当含量10%时，体外降解过程中酸碱度趋于平衡（pH=6.67）。结论 碳酸钙能改变硫酸钙骨水泥的理化性能，当含量为10%时，能够提供最佳的凝固时间，给术者操作提供足够的时间；且不影响硫酸钙凝固后的抗压强度；此外，当含量为10%时，体内降解过程中的酸碱度也有利于促进新骨的形成。但含量大于10%，其降解时间较短，仍需添加其他的改性剂。
Abstract:
【Abstract】 Objective To investigate the effect of basic calcium carbonate on the physical and chemical properties of medical grade calcium sulfate, and to provide a theoretical basis for the preparation of injectable calcium sulfate bone cement with suitable for pH. Methods According to the mass ratio of CaCO3 in calcium sulfate complex, they were divided into 5 groups: 0%, 5%, 10%, 20% and 30%. The powder of bone cement was prepared by fully mixing different contents and surgical grade calcium sulfate. Methylcellulose solution with a concentration of 3% was used as the liquid agent of bone cement. According to the liquid-solid ratio of 0.4 ∶ 1, the powder and liquid of the bone cement are mixed and stirred evenly to form a slurry. According to different molds, the initial setting time, final setting time, compressive strength, in vitro degradation rate and pH value of CaCO3/ calcium sulfate composite were measured and recorded. Results The initial setting time and final setting time of calcium sulfate were (4.96±0.20) min and (5.83±0.12) min, respectively. With the increase of CaCO3 content, the initial setting time and final setting time increased first and then decreased (F=25.428, P<0.001; F=30.780, P<0.001). When the content was 10%, the initial setting time and final setting time were the longest (13.17±1.87 and 14.22±2.00). The compressive strength of pure calcium sulfate is (23.33±6.35) MPa. With the increase of CaCO3 content, the compressive strength first increases and then decreases. When the content is 20%, the maximum compressive strength is (27.33±5.86) MPa; However, there was no significant difference in the effect of CaCO3 on the compressive strength of calcium sulfate (F=1.272, P=0.344). The degradation process of pure calcium sulfate was in acidic environment (pH=5.32), and different content of calcium carbonate could increase the pH value; When the content was 10%, the pH tended to balance (pH=6.67). Conclusion Calcium carbonate can change the physical and chemical properties of calcium sulfate bone cement. When the concentration is 10%, it can provide the best setting time and enough time for the operator; And does not affect the compressive strength of calcium sulfate after solidification; In addition, when the concentration is 10%, the pH in the process of degradation in vivo is also conducive to promote the formation of new bone. However, when the concentration is more than 10%, the degradation time is short, and other modifiers still need to be added.

备注/Memo

备注/Memo:
基金项目：2023年度山东省医务职工科技创新计划联合立项项目（SDYWZGKCJHLH2023061）；2023年度潍坊医学院附属医院科技发展项目（2023FYM013）
更新日期/Last Update: 2024-09-03