肌肉因子对骨骼调控作用的研究进展-中华老年骨科与康复电子杂志

文章信息/Info

Title:: Myokines: muscle as an endocrine organ regulates the bone homeostasis

Author(s):: Zhang Pengfei; Wang Wen.; Department of Orthodontics, School and Hospital of Stomatology, Hebei Key Laboratory of Stomatology, Hebei Technology Innovation Center of Oral Health, Shijiazhuang 050017, China

摘要:: 肌肉与骨骼组织为一体化器官，解剖相邻，相辅相成。肌肉-骨骼单元对于个体的自主运动非常重要，机械负荷是连接两种组织的关键机制。近年来的研究表明，肌肉骨骼间除机械耦合关系外，在循环和局部微环境中存在耦联肌肉和骨骼生长的细胞因子，介导两者间的交互作用。其中骨骼肌分泌的细胞因子称为肌肉因子。常见的肌肉因子包括肌肉生长抑制素（MSTN）、鸢尾素（irisin）、胰岛素样生长因子-1（IGF-1）、成纤维细胞生长因子-2（FGF-2）、白细胞介素6（IL-6）、白细胞介素15（IL-15）、骨甘氨酸（OGN）、骨激活素（OA）等。为了进一步深入了解肌肉因子对骨骼的调控网络及内在机制，本文将对肌肉因子对骨稳态的调控作用进行综述，以期为深入理解肌肉因子对骨骼调控的生物学基础提供新视角，同时为肌肉骨骼相关疾病寻找潜在治疗靶点提供新的思路。

Abstract:: Muscle and skeletal tissues are integrated organs. They are complementary and anatomically adjacent. The muscle-bone unit are important for the voluntary movement of the individual. Mechanical loading is the key mechanism that connects the two tissues. Recent studies have shown that except for the mechanical coupling between muscles and skeletons, there are cytokines in the circulatory and local microenvironment that couple and mediate the interaction between the two tissues. The cytokines secreted by skeletal muscle are called myokines, which including myostatin (MSTN), Irisin, Insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2 (FGF-2), Interleukin-6 (IL-6), Interleukin-15 (IL-15), Osteoglycin (OGN), Osteoactivin (OA). In order to further understand the regulatory network and internal mechanism of muscle factors on bone, we will review the molecular regulation of muscle on bone homeostasis, hoping to provide new perspectives for understanding the biological basis of muscle factors on bone regulation and searching for potential therapeutic targets for musculoskeletal diseases in clinic.