[1]卞修蒙 吴凯 庞亮 王鹏 郑龙坡.2009 年至 2023 年美国成年人类风湿性关节炎与中风之间的关联：NHANES 的一项横断面研究[J].中华老年骨科与康复电子杂志,2025,(05):287-294.[doi:10.3877/cma.j.issn.2096-0263.2025.05.004]
Bian Xiumeng,Wu Kai,Pang Liang,et al.Association between Rheumatoid Arthritis and Stroke in adult humans in the United States from 2009 to 2023: a cross-sectional study from NHANES[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2025,(05):287-294.[doi:10.3877/cma.j.issn.2096-0263.2025.05.004]
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2009 年至 2023 年美国成年人类风湿性关节炎与中风之间的关联：NHANES 的一项横断面研究(
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]
- 卷:
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- 期数:
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2025年05
- 页码:
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287-294
- 栏目:
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- 出版日期:
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2025-10-05
文章信息/Info
- Title:
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Association between Rheumatoid Arthritis and Stroke in adult humans in the United States from 2009 to 2023: a cross-sectional study from NHANES
- 作者:
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卞修蒙1 吴凯2 庞亮2 王鹏1 郑龙坡3; 4
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236000 亳州市第二中医院1；325000 浙江中医药大学附属温州中医院2；200072 上海，同济大学附属第十人民医院骨科3；200072 上海市创伤急救中心4
- Author(s):
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Bian Xiumeng1; Wu Kai2; Pang Liang2; Wang Peng1; Zheng Longpo3; 4.
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1Bozhou Second Chinese Medicine Hospital, Bozhou 236000, China; 2Wenzhou Hospital of Traditional Chinese Medicine affiliated to Zhejiang University of Traditional Chinese Medicine, Wenzhou 325000, China; 3Department of Orthopaedics, Tenth People’s Hospital affiliated to Tongji University, Shanghai 200072, China; 4Shanghai Trauma Emergency Center, Shanghai 200072, China
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- 关键词:
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类风湿性关节炎; 中风; 横断面研究; NHANES
- Keywords:
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Rheumatoid Arthritis; Stroke; Cross-Sectional Study; NHANES
- DOI:
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10.3877/cma.j.issn.2096-0263.2025.05.004
- 文献标志码:
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A
- 摘要:
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目的 本研究旨在探究美国成年人群类风湿性关节炎（RA）与中风风险之间的相关性，利用2009至2023年美国国家健康和营养检查调查（NHANES）的数据资源。方法 我们对NHANES数据库中的36 360名参与者进行了分析，其中包括1 677名RA患者。通过描述性统计呈现了人口统计学特征和基线特征，并使用复杂样本权重来估计人口特征、体质指数（BMI）以及糖尿病、高血压和关节炎的总发病率。随后，在多元线性回归模型中加入具有统计学意义的协变量进行分析，以RA作为预测变量，中风作为结果变量，计算效应值（β）及其95%置信区间（CI）。结果 与非RA个体相比，RA患者的中风风险更高（OR=3.183，95% CI: 2.493，4.064，P＜0.001）。在调整了潜在的混杂因素后，RA与中风之间的正相关性依然存在（OR=1.599，95% CI：1.209，2.114，P=0.004）。分层分析显示，女性RA患者的中风风险增加（OR =1.605，95% CI：1.128，2.282，P=0.008）；年龄小于60岁的RA患者的中风风险增加更为显著（OR=2.686，95% CI：1.679，4.299，P＜0.001）。结论 研究结果揭示了RA与中风风险之间的显著关联，明确了对RA患者进行中风预防和管理的重要性。这些发现为临床决策提供了新的视角，并为未来的公共卫生政策制定提供了科学依据。
- Abstract:
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Objective This study aims to explore the correlation between rheumatoid arthritis (RA) and stroke risk in the adult population of the United States, utilizing data resources from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2023. Methods We analyzed 36,360 participants in the NHANES database, including 1, 677 RA patients. Demographic characteristics and baseline characteristics were presented using descriptive statistics, and complex sample weights were used to estimate population characteristics, body mass index (BMI), and the overall incidence of diabetes, hypertension, and arthritis. Subsequently, in the multivariate linear regression model, covariates with statistical significance were included for analysis, with RA as the predictor variable and stroke as the outcome variable, calculating the effect size (β) and its 95% confidence interval (CI). Results The study found that compared to non-RA individuals, RA patients had a higher risk of stroke (OR=3.183, 95% CI: (2.493, 4.064), P<0.001). After adjusting for potential confounding factors, the positive correlation between RA and stroke still existed (OR=1.599, 95% CI: (1.209, 2.114), P=0.004). Subgroup analysis showed that the risk of stroke increased in female RA patients (OR=1.605, 95%CI: (1.128, 2.282), P=0.008); RA patients under the age of 60 had a more significant increase in stroke risk (OR=2.686, 95% CI: (1.679, 4.299), P<0.001). Conclusions The results of the study reveal a significant association between RA and stroke risk, highlighting the importance of stroke prevention and management in RA patients. These findings provide a new perspective for clinical decision-making and offer a scientific basis for the formulation of future public health policies.
备注/Memo
- 备注/Memo:
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基金项目：“十四五” 国家重点研发计划重点专项（2022YFC2504300）；上海市“科技创新行动计划”生物医药科技支撑专项（23S31905700）
更新日期/Last Update:
2026-05-18