[1]刘文宣　张宇宸　刘文聪　高霞　李涛　张晓琳.CTR 基因多态性与老年男性骨质疏松的相关性研究[J].中华老年骨科与康复电子杂志,2015,(02):19-22.[doi:10.3877/cma.j.issn.2096-0263.2015.02.004]
　Liu Wenxuan,Zhang Yuchen,Liu Wencong,et al.Association between calcitonin receptor gene polymorphism and osteoporosis in elderly men[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2015,(02):19-22.[doi:10.3877/cma.j.issn.2096-0263.2015.02.004]
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CTR 基因多态性与老年男性骨质疏松的相关性研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2015年02期
页码:
19-22
栏目:
基础研究
出版日期:
2015-11-05

文章信息/Info

Title:
Association between calcitonin receptor gene polymorphism and osteoporosis in elderly men
作者:
刘文宣　张宇宸　刘文聪　高霞　李涛　张晓琳
河北医科大学流行病与卫生统计学教研室；河北医科大学第一医院骨科，超声科
Author(s):
Liu Wenxuan;  Zhang Yuchen;  Liu Wencong;  Gao Xia;  Li Tao;  Zhang Xiaolin
Xiaolin.1Department of Epidemiology and Statistics, Hebei Medical University, ; Department of Orthopedic, Department of Ultrasound, The First Hospital of Hebei Medical University
关键词:
受体; 降钙素; 　多态性; 遗传学; 　老年人; 　骨质疏松症
Keywords:
Receptor;  calcitonin; 　Polymorphism;  genotic; 　Aged; 　Osteoporosis
DOI:
10.3877/cma.j.issn.2096-0263.2015.02.004
摘要:
目的　探讨降钙素受体基因（calcitonin receptor，CTR）C1377T 基因多态性与老年 男性人群骨质疏松的相关性。方法　前瞻性收集2014 年8 月至2015 年8 月在河北医科大学第三医 院门诊就诊及住院患者中无亲缘关系且符合纳入及排除标准的老年男性220 例，按照骨质疏松诊断 标准分为骨质疏松症组（n=116）和非骨质疏松症组（n=104）。用聚合酶链反应限制性片段长度 多态性技术检测其CTR 基因多态性，并测量骨质疏松症组患者的跟骨定量超声参数：超声振幅衰 减（broadband ultrasound attenuation ，BUA）、超声声速（speed of sound，SOS） 及刚度（systems technologies inc，STI）。通过比较两组人群中CTR 基因型频率，并分析CTR 基因型与跟骨定量 超声参数之间的关系，探讨CTR 基因多态性与老年男性骨质疏松症的相互关系。结果　骨质疏松 症组CTR 基因型CC 型占81.00%，CT 型占19.00%；非骨质疏松症组CC 型占7 2 . 1 0 % ， CT 型占27.90%，两组比较差异无统计学意义（χ2=2.450，P=0.118）；骨质疏松症组C 等位基因 占90.52%，T 等位基因占9.48%；非骨质疏松症组C 等位基因占86.06%，T 等位基因占13.94%，两 组比较差异无统计学意义（χ2=2.128，P=0.145）。但骨质疏松症患者CT 基因型组的BUA、SOS 和 STI 均明显高于CC 基因型组，差异有统计学意义（P ＜ 0.05）。结论　 CTR 基因多态性不是影响 骨质疏松发病的重要因素，但CTR 基因型和定量超声参数所反映的骨密度、骨强度和骨的结构等指 标均有一定相关性。
Abstract:
　Objective　To investigate the relationship between the C1377T polymorphisms of calcitonin receptor (CTR) gene and the incidence of osteoporosis in Chinese elderly male population. Methods　A total of 220 elderly male outpatients who visited the clinic of the Third Hospital of Hebei Medical University between August 2014 and August 2015 were recruited, and divided into osteoporosis group (n=116) and non-osteoporosis group (n=104) according to the diagnostic criteria of osteoporosis. The genotype of CTR gene was examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP). Broadband ultrasound attenuation (BUA), speed of sound (SOS) and systems technologies inc (STI) of osteoporosis patients were determined by UBIS3000 quantitative ultrasound (QUS). Results　Genotypes CC and CT of CTR gene of osteoporosis group were 81.00% and 19.00%, the genotypes in normal group were 72.10% and 27.90% respectively, and there were no significant differences in the distribution of genotypes between these two groups (χ2=2.450, P=0.118). Three quantitative ultrasound indexes in group of genotype CT were higher than those in genotype CC group. Conclusion　 CTR gene polymorphism may not be the important factors influencing the incidence of osteoporosis. But, CTR gene is connected with bone deity, bone strength and bone structure.

参考文献/References:

1 邱贵兴. 老年骨质疏松性骨折的治疗策略 [J/CD]. 中华老年骨科与 康复电子杂志, 2015, 1(1): 1-5. 2 Urano T. Genetics of osteoporosis [J]. Nihon Rinsho, 2011, 69(7): 1315-1321. 3 Park KA, Park YH, Suh MH, et al. Lifestyle and genetic predictors of stiffness index in community-dwelling elderly korean men and women [J]. Asian Nurs Res (Korean Soc Nurs Sci), 2015, 9(3): 251-258. 4 Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles [J]. Nature, 1994, 367(6460): 284-287. 5 陈圆圆, 陈文玮, 张宏秀. OPG 基因多态性与骨质疏松发病风险 相关性的荟萃分析 [J]. 中国骨质疏松杂志, 2015, 21(9): 1069-1075. 6 Khusainova RI, Seleznyova LI, Mal'tsev AV, et al. Associations between vitamin D-binding protein (DBP) gene polymorphism (TAAA)n and development of osteoporosis in the Volga-Ural region of Russia [J]. Bull Exp Biol Med, 2014, 157(2): 253-257. 7 中国老年学学会骨质疏松委员会. 中国人骨质疏松症诊断标准 专家共识( 第三稿·2014 版) [J]. 中国骨质疏松杂志, 2014, 20(9): 1007-1010. 8 郭纪涛, 谭雄进. 降钙素基因相关肽对骨质疏松症骨组织及胃肠 作用的研究进展 [J]. 中国骨质疏松杂志, 2015, 25(1): 121-124. 9 Zhang H, Tao X, Wu J. Association of calcitonin receptor gene polymorphism with bone mineral density in postmenopausal Chinese women: a meta-analysis [J]. Arch Gynecol Obstet, 2015, 291(1): 165- 172. 10 Kherad M, Mellstr?m D, Rosengren BE, et al. The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis [J]. Bone Joint J, 2015, 97-B(8): 1106-1110. 11 徐江波, 高云, 殷剑, 等. 新疆汉族与维吾尔族女性原发性骨质疏 松患者降钙素受体基因多态性的对比研究 [J]. 中华实用诊断与治 疗杂志, 2014, 28(5): 450-452. 12 李志宏, 周振华, 谢菊英, 等. 失神经制动不同时间大鼠降钙素基 因相关肽水平变化及对骨密度的影响 [J]. 中国组织工程研究与临 床康复, 2009, 13(20):3933-3937.

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备注/Memo

备注/Memo:
河北省科技计划项目（132777246）
更新日期/Last Update: 2015-12-30