[1]江晨,崔华,龚江峰,等.术后使用右美托咪定对老年髋部手术患者发生谵妄的临床研究[J].中华老年骨科与康复电子杂志,2018,(06):336-340.[doi:10.3877/cma.j.issn.2096-0263.2018.06.004]
　iang Chen,Cui Hua,Gong Jiangfeng,et al.Clinical study of dexmedetomidine on postoperative delirium in elderly patients following hip surgery[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(06):336-340.[doi:10.3877/cma.j.issn.2096-0263.2018.06.004]
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术后使用右美托咪定对老年髋部手术患者发生谵妄的临床研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2018年06期
页码:
336-340
栏目:
髋关节
出版日期:
2018-11-23

文章信息/Info

Title:
Clinical study of dexmedetomidine on postoperative delirium in elderly patients following hip surgery
作者:
江晨; 崔华; 龚江峰; 徐辉
226100 海门市人民医院骨科
Author(s):
iang Chen;  Cui Hua;  Gong Jiangfeng;  Xu Hui
Department of Orthopaedics, Haimen People’s Hospital, Haimen 226100, China.
关键词:
右美托咪定;  术后谵妄;  老年人;  髋
Keywords:
Dexmedetomidine;  Postoperative delirium;  Aged;  Hip
DOI:
10.3877/cma.j.issn.2096-0263.2018.06.004
文献标志码:
A
摘要:
目的 探讨术后使用右美托咪定对老年髋部手术患者发生谵妄的影响。方法 前瞻性收集2016年1月至2018年1月在海门市人民医院骨科行髋部手术的老年患者50例，采用随机数字表法将患者分为两组：右美托咪定组25例，术后在骨科常规治疗基础上给予右美托咪定静脉泵入注射用于术后镇痛，维持量0.5 μg/kg/hr；对照组25例，仅给予骨科常规治疗。比较两组谵妄的发生率、发生时间、持续时间。结果 全部患者均获得随访，随访时间为7～15 d，平均（10.0±1.4）d。右美托咪定组谵妄的发生率（6%）与对照组（13%）比较，差异无统计学意义（P＞0.05）。右美托咪定组谵妄的发生时间为术后（26±6）h，晚于对照组的（7±3）h，差异有统计学意义（t=2.370，P＜0.05）。右美托咪定组谵妄的持续时间为（2.4±0.8）d，短于对照组的（6.2±1.5）d，差异有统计学意义（t=-1.942，P＜0.05）。结论 右美托咪定能延缓谵妄的发生，缩短谵妄的持续时间，但不能显著降低谵妄的发生率。
Abstract:
Objective To explore the effect of dexmedetomidine on postoperative delirium in elderly patients following hip surgery. Methods Fifty patients over 65 years following hip surgery were admitted from January 2016 to to January 2018, they were randomly divided into two groups: dexmedetomidine group (n=25) which was given dexmedetomidine for postoperative analgesia with a does of 0.5 μg/kg/hr followed by orthopedic routine treatment and control group (n=25) which was only given with routine treatment. The incidence, onset time and duration of delirium were compared between two groups. Results All patients were well followed up with a mean duration of (10.0±1.4) days (range, 7-15 days). There was no statistical difference between dexmedetomidine group (6%) and control group (13%) on the incidence of delirium (P>0.05). There was significant difference between dexmedetomidine group [(26±6) h] and control group [(7±3) h] on the onset time of delirium (t=2.370, P<0.05). There was significant difference between dexmedetomidine group [(2.4±0.8) d] and control group [(6.2±1.5) d] on the duration of delirium (t=-1.942, P<0.05). Conclusion Dexmedetomidine could delay the onset time and shorten the duration of delirium, but could not lower the incidence of delirium.

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备注/Memo

备注/Memo:
基金项目：海门市科技计划项目（2017SF12）
更新日期/Last Update: 2018-11-23