[1]芦晶晶,李星,娄萍萍,等.血清铁蛋白水平与骨密度的相关性研究[J].中华老年骨科与康复电子杂志,2020,(02):111-116.[doi:10.3877/cma.j.issn.2096-0263.2020.02.009]
　Lu Jingjing,Li Xing,Lou Pingping,et al.The relationship between Serum ferritin and Osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2020,(02):111-116.[doi:10.3877/cma.j.issn.2096-0263.2020.02.009]
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血清铁蛋白水平与骨密度的相关性研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2020年02期
页码:
111-116
栏目:
骨质疏松
出版日期:
2020-04-05

文章信息/Info

Title:
The relationship between Serum ferritin and Osteoporosis
作者:
芦晶晶; 李星; 娄萍萍; 张洁; 刘岩; 周亚茹
050051 石家庄，河北医科大学第三医院内分泌科
Author(s):
Lu Jingjing;  Li Xing;  Lou Pingping;  Zhang Jie;  Liu Yan;  Zhou Yaru
Departmen tof Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
关键词:
骨密度;  骨质疏松症;  铁过载;  血清铁蛋白
Keywords:
Bone density;  Osteoporosis;  Iron?overload;  Serum ferritin
DOI:
10.3877/cma.j.issn.2096-0263.2020.02.009
文献标志码:
A
摘要:
目的 分析绝经后女性及50岁以上男性不同骨量人群血清铁蛋白的差异，探讨血清铁蛋白水平与骨密度的相关性。方法 选择2018年9月至2019年2月期间于河北医科大学第三医院就诊，接受双能X线骨密度测量仪（DEXA）检测骨密度（BMD）的绝经后女性（131例）及50岁以上男性（65例）患者（共196例），根据BMD分为骨量正常组（46例）、骨量减少组（68例）和骨质疏松组（82例）。收集上述患者的临床资料，检测相关生化指标，并测定血清铁蛋白水平，评估血清铁蛋白与骨密度的相关性。结果 （1）与骨量正常组[99.50（91.55，128.51）ng/ml]和骨量减少组[103.36（93.26，113.46）ng/ml]相比，骨质疏松组血清铁蛋白水平明显增高[（174.25（160.85，210.42）ng/ml）（c2=100.573，P=0.000）。（2）血清铁蛋白水平与髋部、腰椎骨密度均呈负相关，（髋部r=-0.487，P＜0.05；腰椎r=-0.531，P＜0.05）。（3）体重为骨质疏松症的保护因素（r=0.049，P＜0.05），血清铁蛋白为骨质疏松症的危险因素（r=-0.018，P＜0.05）。结论 血清铁蛋白水平增高是骨质疏松症的危险因素，在骨质疏松症的发生中可能起重要作用。
Abstract:
Objective To analyze the difference of serum ferritin among postmenopausal women and men older than 50 years with different bone mass, and to explore the correlation between serum ferritin level and bone mineral density (BMD). Methods Postmenopausal women (n=131) and men (n=65) older than 50 years who received DEXA from September 2018 to February 2019 were enrolled in this study. They were divided into normal (46 cases), osteopenia (68 cases) and osteoporosis (82 cases) groups. Clinical data and biochemical parameters were collected. The level of serum ferritin was detected, and its correlation with BMDwas also determined. Results 1. Compared with normal and osteopenia group, serum ferritin level was significantly increased in osteoporosis group [174.25 (160.85, 210.42) ng/ml vs. 99.50 (91.55, 128.51) ng/ml and 103.36 (93.26, 113.46) ng/ml, c2=100.573, P<0.05]. 2. The level of serum ferritin was negatively correlated with BMD in hip and lumbar spine (hip r=-0.487, P<0.05; lumbar vertebrae r=-0.531, P<0.05). 3. Multivariate binary logistic regression analysis showed that body weight was the protective factor for osteoporosis (r=0.049, P<0.05), and serum ferritin was the risk factor for osteoporosis (r=-0.018, P<0.05). Conclusion Serum ferritin plays an important role in the prevalence of osteoporosis, which may be a risk factor for osteoporosis

参考文献/References:

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备注/Memo

备注/Memo:
河北省重点研发计划国际科技合作专项（18397749D）
更新日期/Last Update: 2020-07-07