[1]李子怡,李玉坤.OPG/RANK/RANKL信号通路在骨质疏松症中的研究进展和应用[J].中华老年骨科与康复电子杂志,2017,(02):124-128.[doi:10.3877/cma.j.issn.2096-0263.2017.02.012]
　Li Ziyi,Li Yukun.Researching progress and application of OPG-RANK-RANKL signaling pathway in osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2017,(02):124-128.[doi:10.3877/cma.j.issn.2096-0263.2017.02.012]
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OPG/RANK/RANKL信号通路在骨质疏松症中的研究进展和应用()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2017年02期
页码:
124-128
栏目:
综述
出版日期:
2017-03-25

文章信息/Info

Title:
Researching progress and application of OPG-RANK-RANKL signaling pathway in osteoporosis
作者:
李子怡; 李玉坤
050051石家庄，河北医科大学第三医院内分泌二科
Author(s):
Li Ziyi;  Li Yukun
The second department of endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
关键词:
骨质疏松症;  骨重建;  骨保护蛋白;  核因子-Kβ受体活化因子
Keywords:
Osteoporosis;  Bone remodeling;  Osteoprotegerin;  RANK
DOI:
10.3877/cma.j.issn.2096-0263.2017.02.012
文献标志码:
A
摘要:
骨保护蛋白（OPG）/核因子-Kβ受体活化因子（RANK）/核因子-Kβ受体活化因子配体（RANKL）信号通路是调节骨重建过程中破骨细胞功能的重要通路。成骨细胞释放的 RANKL与破骨细胞表面的 RANK结合后通过 NF-Kβ途径、JNK途径、蛋白激酶 B途径等促进破骨细胞的分化和激活； OPG则可竞争性抑制 RANK与 RANKL的结合，抑制破骨细胞功能，减少骨质破坏。OPG与 RANKL的比例是调节骨吸收和骨形成平衡的重要因素。目前，该通路相关药物治疗骨质疏松的研究取得了一定的进展。本文对 OPG/RANK/RANKL信号通路在骨循环中的作用机制和相关影响因素进行了综述，旨在为骨质疏松的防治提供新的思路。
Abstract:
Osteoprotegerin/receptor- activator of nuclear factor kappa beta/receptor- activator of nuclear factor kappa beta ligand is important pathway in regulation of osteoclast and bone remodeling. The osteoblast release RANKL first bind with RANK locat in the osteoclast surface, differentiation and activation of osteoclast are then promoted through NF-Kβ pathway, the JNK pathway, protein kinase B pathway and so on. OPG competitively inhibit the combination of RANK and RANKL, lower the osteoclast function and further reduce bone destruction. To summarize, one of the most important factor of bone resorption and formation balance is the proportion of OPG and RANKL. At present, regard to certain developments of relative osteoporosis medicine have been achieved, this article aim to describe the mechanism and related factors of OPG-RANK-RANKL signaling pathway in bone cycle, and provide a new prevention and cure approach for osteoporosis.

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备注/Memo

备注/Memo:
基金项目：2016年政府资助省级临床医学优秀人才项目
更新日期/Last Update: 2017-04-05