[1]鲍晓雪,王娜,李玉坤,等.血清OPG、TGF-β和IL-6水平对绝经后骨量减少合并2型糖尿病患者骨折风险的预测[J].中华老年骨科与康复电子杂志,2018,(01):9-13.[doi:10.3877/cma.j.issn.2096-0263.2018.01.003]
　Bao Xiaoxue,Wang Na,Li Yukun,et al.Prediction of fracture risk in postmenopausal type 2 diabetes mellitus with osteopenia by serum OPG, TGF-β and IL-6 levels[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(01):9-13.[doi:10.3877/cma.j.issn.2096-0263.2018.01.003]
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血清OPG、TGF-β和IL-6水平对绝经后骨量减少合并2型糖尿病患者骨折风险的预测()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2018年01期
页码:
9-13
栏目:
骨质疏松
出版日期:
2018-01-31

文章信息/Info

Title:
Prediction of fracture risk in postmenopausal type 2 diabetes mellitus with osteopenia by serum OPG, TGF-β and IL-6 levels
作者:
鲍晓雪; 王娜; 李玉坤; 王燕; 薛鹏
050051 石家庄，河北医科大学第三医院内分泌二科
Author(s):
Bao Xiaoxue;  Wang Na;  Li Yukun;  Wang Yan;  Xue Peng
Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
关键词:
糖尿病; 2型;  骨质疏松症;  血清反应因子;  骨折风险
Keywords:
Diabetes mellitus;  Type 2;  Osteoporosis;  Serum response factor;  Fracture risk
DOI:
10.3877/cma.j.issn.2096-0263.2018.01.003
文献标志码:
A
摘要:
目的 研究绝经后骨量减少合并2型糖尿病（T2DM）患者血清骨保护素（OPG）、转化生长因子-β（TGF-β）和白细胞介素-6（IL-6）水平的变化；评估血清OPG、TGF-β和IL-6水平对绝经后骨量减少合并T2DM患者10年骨折风险的影响；分析上述因子在绝经后T2DM患者骨折进展中的作用。方法 该回顾性研究共纳入128名绝经后骨量减少患者，其中64名合并T2DM患者（-2.5＜T值＜-1.0）为实验组，并将64名单纯骨量减少患者（糖代谢正常）设置为对照组；比较两组骨密度（BMD）、血清OPG、TGF-β和IL-6水平；应用骨折风险评估工具对上述研究对象的10年骨折风险进行预测，评估不同血清因子与10年骨折风险的相关性。结果 绝经后骨量减少合并T2DM患者的BMD与单纯骨量减少患者的BMD之间没有统计学差异（Z=0.841，P＞0.05）；绝经后骨量减少合并T2DM患者血清OPG（Z=2.264，P=0.024）、TGF-β（Z=2.836，P=0.005）和IL-6（Z=2.431，P=0.015）水平高于单纯骨量减少患者；两组患者的血清OPG、TGF-β、IL-6水平与10年骨折风险均存在相关性。结论 绝经后骨量减少合并T2DM患者的促炎细胞因子和OPG水平高于单纯骨量减少患者，促炎因子TGF-β和IL-6水平的升高对于预测绝经后骨量减少合并T2DM患者的骨折风险具有重要意义。
Abstract:
Objective To evaluate the variations of serum OPG, TGF-β and IL-6 levels with bone loss in postmenopausal women with or without type 2 diabetes mellitus (T2DM), to elucidate the role of serum OPG, TGF-β and IL-6 levels in prediction for 10-year probability of fracture risk, and to explore the impact of serum OPG, TGF-β and IL-6 levels on the progression of type 2 diabetic fracture. Methods This study included 128 postmenopausal women who were diagnosed as osteopenia (areal bone mineral density at spine and hip of all subjects were measured by DXA, patients with T score more than -2.5 and less than -1.0 were diagnosed as osteopenea). They were divided into two groups, T2DM group and non-T2DM group. Besides of BMD, all subjects were measured the serum levels of OPG, TGF-β and IL-6. Furthermore, we predicted the 10-year probability of fracture risk in all cohorts by FRAX? and analyzed the correlations of the risk with serum levels of OPG, TGF-β and IL-6 in all subjects. Results There were no significant differences of BMD between the two groups (Z=0.841, P>0.05). However, the serum levels of OPG (Z=2.264, P=0.024), TGF-β (Z=2.836, P=0.005) and IL-6 (Z=2.431, P=0.015) in T2DM group were higher than that in non-T2DM group. Furthermore, the serum levels of OPG, TGF-β and IL-6 were correlated with the 10-year probability of fracture risk in T2DM group. Conclusion The serum levels of OPG, TGF-β and IL-6 increased in osteopenia patients with T2DM, suggesting that the increased inflammatory factors could be used as predictors for the 10-year probability of fracture risk in osteopenia patients with T2DM.

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备注/Memo

备注/Memo:
基金项目：河北省自然科学基金（H2016206243）；河北省高等学校自然科学青年拔尖人才项目（BJ2016037）
更新日期/Last Update: 2018-01-31