[1]王娟,高俊,周伊兰,等.血清IL-2、IL-17和骨密度关系及其对骨质疏松症的预测价值[J].中华老年骨科与康复电子杂志,2023,(05):295-300.[doi:10.3877/cma.j.issn.2096-0263.2023.05.007]
　Wang Juan,Gao Jun,Zhou Yilan,et al.Relationship between serum IL-2, IL-17 and bone mineral density and their predictive value for osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2023,(05):295-300.[doi:10.3877/cma.j.issn.2096-0263.2023.05.007]
点击复制

血清IL-2、IL-17和骨密度关系及其对骨质疏松症的预测价值()
分享到：

中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2023年05期
页码:
295-300
栏目:
骨质疏松
出版日期:
2023-10-05

文章信息/Info

Title:
Relationship between serum IL-2, IL-17 and bone mineral density and their predictive value for osteoporosis
作者:
王娟1; 高俊2; 周伊兰1; 李小红1; 史兵伟1; 潘美珍1
213003 南京中医药大学常州附属医院检验科1，中医正骨科2
Author(s):
Wang Juan1;  Gao Jun2;  Zhou Yilan1;  Li Xiaohong1;  Shi Bingwei1;  Pan Meizhen1.
1Department of Laboratory Medicine, 2Department of Chinese Traditional Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou 213003, China
关键词:
骨质疏松;  淋巴细胞;  IL-17;  ROC
Keywords:
osteoporosis;  lymphocyte;  IL-2;  IL-17
DOI:
10.3877/cma.j.issn.2096-0263.2023.05.007
文献标志码:
A
摘要:
目的 检测骨质疏松症患者体内淋巴细胞亚群相应细胞因子的表达并进一步探讨其与疾病的相关性，探讨白介素-2（IL-2）和白介素-17（IL-17）对于骨质疏松疾病诊断的预测价值。方法 收集40例骨质疏松症[男13例，女27例，年龄（75.58±1.90）岁]和35例[男10例，女25例，年龄（71.67±1.99）岁]年龄相仿的健康人血清样本，使用流式细胞术、化学发光法分别检测其淋巴细胞亚群相应细胞因子水平、Ⅰ型胶原羧基端前肽（PINP）及 β-胶原降解产物（β-CTX）水平；使用双能X线骨密度仪检测受试者骨密度；使用受试者工作曲线评价IL-17和IL-2的预测效能。结果 较健康对照组[（386.9±39.81）pg/ml]相比，骨质疏松症患者体内 β-CTX表达上调[（563.7±57.25）pg/ml]，差异具有统计学意义（P＜0.05）；PINP表达具有上调趋势，差异无统计学意义；此外IL-2、IL-10、IL-17呈现明显高表达（P＜0.05）；进一步分析发现IL-2和IL-17的表达与骨密度具有明显的相关性（r=-0.272，r=-0.380，P＜0.05），ROC曲线进一步计算出IL-17和IL-2曲线下面积分别为0.874和0.625。结论 骨质疏松患者IL-17和IL-2表达水平明显上调，且IL-17可作为骨质疏松症诊断的预测指标。
Abstract:
Objective To detect the expression of cytokines corresponding to lymphocyte subpopulations in patients with osteoporosis and further investigate their correlation with osteoporosis, and to explore the predictive value of interleukin-17 (IL-17) and interleukin-2 (IL-2) of osteoporosis. Methods Serum samples were collected from 40 cases (13 males and 27 females, 75.58±1.90 years) of osteoporosis and 35 healthy subjects (10 males and 25 females, 71.67±1.99 years) of similar age, and their lymphocyte subpopulation corresponding cytokine levels, type I collagen carboxy-terminal prepeptide (PINP) and β-collagen degradation product (β-CTX) levels were measured using flow cytometry and chemiluminescence, respectively; BMD of the patients was measured using dual-energy X-ray bone densitometry; the working curves of the subjects were used to evaluate the predictive efficacy of IL 17 and IL-2 predictive efficacy by subject work curves. Results Compared to healthy controls (386.9±39.81 pg/ml), β-CTX expression was up-regulated in osteoporosis patients (563.7±57.25 pg/ml) with statistically significant differences (P<0.05), and PINP expression had a tendency to be up-regulated without statistically significant differences; in addition, IL-2, IL-10 and IL-17 showed significantly high expression (P<0.05), while only the expression of IL-2 and IL-17 correlated with BMD (r=-0.272，r=-0.380，P<0.05); further the ROC curve calculated that the area under the curve of IL-17 and IL-2 were 0.874 and 0.625, respectively. Conclusions IL-17 and IL-2 expression levels were significantly up-regulated in osteoporotic patients, and IL-17 can be used as a predictor for the diagnosis of osteoporosis.

相似文献/References:

[1]张玺,胡永成,耿欣,等.老年肱骨近端骨折患者皮质骨厚度与骨密度相关性分析[J].中华老年骨科与康复电子杂志,2015,(01):16.
[2]周冉冉,赵小芹,王鑫蕾,等.FRAX、OSTA与骨代谢指标在评价绝经后2型糖尿病患者骨密度中的临床价值[J].中华老年骨科与康复电子杂志,2022,(04):237.[doi:10.3877/cma.j.issn.2096-0263.2022.04.008]
　Zhou Ranran,Zhao Xiaoqin,Wang Xinlei,et al.Clinical study of FRAX, OSTA and bone metabolism indexes in evaluating bone mineral density in postmenopausal patients with Type 2 diabetes[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2022,(05):237.[doi:10.3877/cma.j.issn.2096-0263.2022.04.008]
[3]王燕,李文静,吕红芝,等.骨质疏松骨折临床预测模型的建立与评价[J].中华老年骨科与康复电子杂志,2022,(06):350.[doi:10.3877/cma.j.issn.2096-0263.2022.06.006]
　Wang Yan,Li Wenjing,Lyu Hongzhi,et al.Establishment and Evaluation of Clinical Predictive Model for Osteoporotic fracture[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2022,(05):350.[doi:10.3877/cma.j.issn.2096-0263.2022.06.006]
[4]周锐,罗飞.骨质疏松椎体骨折的分型进展[J].中华老年骨科与康复电子杂志,2024,(05):315.[doi:10.3877/cma.j.issn.2096-0263.2024.05.009]
　Zhou Rui,Luo Fei..Osteoporotic vertebral fracture- the evolution of classification and progress in treatment[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2024,(05):315.[doi:10.3877/cma.j.issn.2096-0263.2024.05.009]

备注/Memo

备注/Memo:
基金项目：常州市科技局科技计划（应用基础项目）CJ20210162；江苏省科技计划项目（社会发展）BE2019653
更新日期/Last Update: 2023-10-25