[1]王芳,刘达,左智炜,等.定量CT与双能X线骨密度仪对骨质疏松诊断效能比较的Meta分析[J].中华老年骨科与康复电子杂志,2024,(06):363-371.[doi:10.3877/cma.j.issn.2096-0263.2024.06.007]
　Wang Fang,Liu Da,Zuo Zhiwei,et al.Meta-analysis of quantitative CT and dual energy X-ray absorptiometry in the diagnosis of osteoporosis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2024,(06):363-371.[doi:10.3877/cma.j.issn.2096-0263.2024.06.007]
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定量CT与双能X线骨密度仪对骨质疏松诊断效能比较的Meta分析()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2024年06期
页码:
363-371
栏目:
Meta分析
出版日期:
2024-12-05

文章信息/Info

Title:
Meta-analysis of quantitative CT and dual energy X-ray absorptiometry in the diagnosis of osteoporosis
作者:
王芳1; 刘达2; 左智炜1; 盛金平1; 陈庭进2; 蒋锐1
610083 成都，中国人民解放军西部战区总医院放射诊断科1 ，骨科2
Author(s):
Wang Fang1;  Liu Da2;  Zuo Zhiwei1;  Sheng Jinping1;  Chen Tingjin2;  Jiang Rui1.
1Department of Radiology Diagnostics, 2Department of Orthopedics, The General Hospital of Western Theater Command , Chengdu 610083, China
关键词:
定量CT;  双能X线;  骨质疏松;  比较;  Meta分析
Keywords:
Quantitative CT;  Dual Energy X-ray;  Osteoporosis;  Comparison;  Meta-analysis
DOI:
10.3877/cma.j.issn.2096-0263.2024.06.007
文献标志码:
A
摘要:
目的 比较定量CT与双能X线骨密度仪对骨质疏松的诊断价值。方法 检索自建库起至2022年2月PubMed、FEBM、The Cochrane Library、CBM、知网、万方数据库、维普等数据库，以纳入以定量CT和（或）双能X线骨密度仪诊断骨质疏松的相关研究，收集能构建2*2列联表的文献。按照诊断试验的纳入和排除标准筛选文献，运用QUADAS-2文献质量评价工具及ReviewManager 5.4软件评价纳入文献的质量和偏倚风险，采用Stata 14.0 软件进行Meta分析。结果 最终纳入21篇文献，Meta分析结果显示，定量CT诊断骨质疏松的合并敏感性（Sen合并）为0.94 [95% CI：0.84，0.98]，特异性（Spe合并）为0.55 [95% CI：0.31，0.77]，阳性似然比（+LR合并）为2.1 [95% CI：1.2，3.8]，阴性似然比（-LR合并）为0.11（95% CI：0.03，0.41）；双能X线诊断骨质疏松的合并敏感性（Sen合并）为0.70 [95% CI：0.36，0.91]，特异性（Spe合并）为0.86 [95% CI，：0.55，0.97]，阳性似然比（+LR合并）为5.1 [95% CI：1.2，20.9]，阴性似然比（-LR合并）为0.34（95% CI：0.12，0.95），两者的诊断比值比（DOR合并）分别为18（95% CI：3，110）和15（95% CI：2，115）；SROC曲线下面积分别为0.89 [95% CI：0.85，0.91]和0.86 [95% CI：0.83，0.89]。结论 定量CT和双能X线在骨质疏松的诊断中均具有较高的应用价值，常规检查中可以优先选择诊断效能更高的定量CT。
Abstract:
Objective To compare the diagnostic value of quantitative CT and dual-energy X-ray absorptiometry for osteoporosis. Methods PubMed, FEBM, The Cochrane Library, CBM, CNKI, Wanfang Database, VIP and other databases were searched from the establishment of the database to February 2022 to include relatedstudieson the diagnosis of osteoporosis by quantitative CT and (or) dual-energy X-ray absorptiometry, collect literature that can construct a 2x2 contingency table. The literatures were screened according to the inclusion and exclusion criteria of diagnostic tests, and the quality and risk of bias of the included literature were evaluated by QUADAS-2 literature quality assessment tool and ReviewManager 5.4 software, and Meta-analysis was performed by Stata 14.0 software. Results Twenty-one articles were finally included. The meta-analysis showed that the combined sensitivity (Sen combined) of quantitative CT in the diagnosis of osteoporosis was0.94 [95% CI: 0.84, 0.98], and the specificity (Spe combined) was 0.55 [95% CI: 0.31, 0.77], the positive likelihood ratio (+LR combined) was 2.1 [95% CI: 1.2, 3.8], and the negative likelihood ratio (-LR combined) was 0.11 (95% CI: 0.03, 0.41); dual energy The combined sensitivity (Sen combined) of X-rays for the diagnosis of osteoporosis was 0.70 [95% CI: 0.36, 0.91], the specificity (Spe combined) was 0.86 [95% CI: 0.55, 0.97], and the positive likelihood ratio (+LR pooled) was 5.1 [95% CI: 1.2, 20.9], negative likelihood ratio (-LR pooled) was 0.34 (95% CI: 0.12, 0.95), and the respective diagnostic odds ratios (DOR pooled) were 18 (95% CI: 3, 110) and 15 (95% CI: 2, 115);the areas under the SROC curve were 0.89 [95% CI: 0.85, 0.91] and 0.86 [95% CI: 0.83, 0.89], respectively. Conclusion Both quantitative CT and dual-energy X-ray have high application value in the diagnosis of osteoporosis, and quantitative CT with higher diagnostic efficiency can be preferred in routine examination.

备注/Memo

备注/Memo:
基金项目：四川省自然科学基金面上项目（2022NSFSC0664）；青年孵化项目（2021-XZYG-C04）
更新日期/Last Update: 2025-03-10