[1]薛士麟,李姿萱,王冰霜,等.中国人群维生素D受体rs7975232和rs1544410位点基因多态性与骨质疏松症相关性的meta分析[J].中华老年骨科与康复电子杂志,2020,(04):236-242.[doi:10.3877/cma.j.issn.2096-0263.2020.04.009]
　Xue Shilin,Li Zixuan,Wang Bingshuang,et al.Association of vitamin D receptor rs7975232 and rs1544410 gene polymorphisms with osteoporosis in Chinese population: a meta-analysis[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2020,(04):236-242.[doi:10.3877/cma.j.issn.2096-0263.2020.04.009]
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中国人群维生素D受体rs7975232和rs1544410位点基因多态性与骨质疏松症相关性的meta分析()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2020年04期
页码:
236-242
栏目:
综述
出版日期:
2020-08-05

文章信息/Info

Title:
Association of vitamin D receptor rs7975232 and rs1544410 gene polymorphisms with osteoporosis in Chinese population: a meta-analysis
作者:
薛士麟1; 李姿萱2; 王冰霜3; 翟佳慧4; 贾金海4
100191 北京大学医学部基础医学院1；050017 石家庄，河北医科大学基础医学院2；050017 石家庄，河北医科大学研究生学院3；050017 石家庄，河北医科大学门诊部4
Author(s):
Xue Shilin1;  Li Zixuan2;  Wang Bingshuang3;  Zhai Jiahui3;  Jia Jinhai3.
1Department of basic medicine，Peking University Health Science Center，Beijing 100191, China; 2Department of basic medicine, 3Graduate school, 4Outpatient Clinic, Hebei Medical University, Shijiazhuang 050017, China
关键词:
基因多态性;  骨质疏松症;  维生素D受体基因;  Meta分析
Keywords:
Gene polymorphism;  Osteoporosis;  Vitamin D receptor gene;  Meta analysis
DOI:
10.3877/cma.j.issn.2096-0263.2020.04.009
文献标志码:
A
摘要:
目的 本研究采用meta分析的方法，探讨了中国人维生素D受体基因多态性与骨质疏松的关系。方法 检索CNKI、万方、维普、Pubmed、Web of Science、Embase数据库，检索时间从建库至2020年3月，从数据库中检索有关维生素D受体（rs7975232和rs1544410）基因多态性和骨质疏松症之间相关性的文章。采用NOS文献质量评价标准对符合纳入排除标准的文献进行质量评价。采用OR值及其95%可信区间（95% CI）评估关联强度。根据是否存在异质性，采用固定效应模型或随机效应模型合并效应量。采用单因素敏感性分析法进行敏感性分析。结果 本研究最终共纳入20项符合条件的研究，包括4 468例病例和4 988名对照。在等位基因模型中，rs7975232和rs1544410的合并OR估计值分别为1.09（95% CI：0.84，1.39，P=0.524）和0.9（95% CI：0.57，1.43，P=0.659），尚未发现两个位点与骨质疏松症的关联。在显性模型、隐性模型和共显性模型中，结果均未显示二者的相关性。结论 在中国人群中，维生素D受体（rs7975232和rs1544410）基因多态性与骨质疏松风险之间无关联。
Abstract:
Objective To investigate the relationship between vitamin D receptor gene polymorphism and osteoporosis in Chinese. Methods CNKI, Wanfang, VIP, PubMed, web of science and EMBASE databases were searched from the database establishment to March 2020. Articles on the relationship between vitamin D receptor (rs7975232 and rs1544410) gene polymorphism and osteoporosis were searched from the database. The NOS standard was used to evaluate the quality of the literatures that met the inclusion and exclusion criteria. OR value and its 95% confidence interval (95% CI) were used to evaluate the association strength. According to the heterogeneity, the fixed effect model or random effect model was used to combine the effect amount. A single factor sensitivity analysis method was used for sensitivity analysis. Results A total of 20 eligible studies including 4 468 cases and 4 988 controls were included. In the allelic model, the pooled or estimates of rs7975232 and rs1544410 were 1.09 (95% CI: 0.84, 1.39, P=0.524) and 0.9 (95% CI: 0.57, 1.43, P=0.659), respectively. The association between the two SNPs and osteoporosis has not been found. In addition, the results showed no significant correlation in the dominant model, invisible model and co dominant model. Conclusion There is no significant association between vitamin D receptor gene polymorphism and osteoporosis risk in Chinese population.

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更新日期/Last Update: 2020-08-18