[1]宋会平,张柳.阿仑膦酸钠治疗老年女性严重骨质疏松症患者的疗效分析[J].中华老年骨科与康复电子杂志,2016,(03):141-145.[doi:10.3877/cma.j.issn.2096-0263.2016.03.003]
　Song Huiping,Zhang Liu.Effcacy analysis of alendronate in the treatment of severe osteoporosis in senile women[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2016,(03):141-145.[doi:10.3877/cma.j.issn.2096-0263.2016.03.003]
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阿仑膦酸钠治疗老年女性严重骨质疏松症患者的疗效分析()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2016年03期
页码:
141-145
栏目:
骨质疏松
出版日期:
2016-08-05

文章信息/Info

Title:
Effcacy analysis of alendronate in the treatment of severe osteoporosis in senile women
作者:
宋会平; 张柳
063000 唐山，华北理工大学附属医院骨科
Author(s):
Song Huiping;  Zhang Liu
Department of Orthopedics, the Affliated Hospital of North China University of Science and Technology, Tangshan 06300, China
关键词:
阿仑膦酸钠; 　老年人; 　女性; 　骨质疏松症; 　骨折
Keywords:
Alendronate;  Aged;  Women;  Osteop
DOI:
10.3877/cma.j.issn.2096-0263.2016.03.003
文献标志码:
A
摘要:
目的 探讨阿仑膦酸钠治疗老年女性严重骨质疏松症患者的临床疗效。 方法 回顾性分析华北理工大学附属医院骨质疏松门诊 2013 年 1 月至 2015 年 8 月期间诊治的骨质疏松伴陈旧骨折的老年女性患者 52 例，年龄 60 ～ 86 岁，平均（69±7）岁，平均绝经时间（16±6）年。均在每日联用骨化三醇 0.25 ug 和碳酸钙 D3 片 600 mg 的基础上，每周 1 次口服阿仑膦酸钠 70 mg，连续治疗 1 年。 随访并记录患者治疗前后不同时间的骨密度（BMD）及其变化率、疼痛视觉模拟评分（VAS）、生化指标、影像学资料等评估治疗效果，观察再骨折和不良反应情况。 结果 52 例患者均获得完整随访，随访时间为（12.7±1.2） 个月。与治疗前相比，腰椎和股骨颈部位的 BMD 值在治疗后 3、 6、 12 个月时均明显增加，差异具有统计学意义（F=102.633， F=25.413， P ＜ 0.05）， VAS 评分均明显降低，差异具有统计学意义（F=76.499， P ＜ 0.05）， 6 个月内骨痛明显改善，但 6 个月后骨痛有增加趋势；安全性评价显示治疗前后血尿常规、肝肾功能、钙、磷、碱性磷酸酶等生化指标检测均在正常范围；治疗期间 3 例再发椎体骨折，无严重不良反应出现。 结论 阿仑膦酸钠可有效治疗老年女性严重骨质疏松症，增加骨量，缓解骨痛，短期内无严重不良反应发生，但长期服用的安全性、有效性还有待于进一步观察。
Abstract:
Objective To investigate the clinical effcacy of alendronate in the treatment of severe osteoporosis in elderly female. Methods Retrospective review was conducted in 52 elderly females with osteoporotic associated with old fractures from January 2013 to August 2015, the average age was 69±7 years, average time after menopause was 16±6 years. All patients took oral medication of 0.25 ug calcitriol and 600 mg calcium carbonate with Vitamin D3 per day as a basic treatment, in addition with 70 mg alendronate a week, and the treatment sustained for one year. Bone mineral density (BMD), visual analogue scale (VAS), imaging analyses and biochemical tests were recorded to evaluate the clinical effcacy before and after alendronate intervention at different time point. The adverse events and the recurrence of fractures were also observed. Results All the 52 patients were followed up for (12.7±1.2) months. Compared with that before treatment, BMD values were signifcant increased, and the VAS scores were signifcant decreased at 3, 6 and 12 months after treatment (P<0.05). VAS scores showed signifcant decreased at 6 months while increased tendency was showed after 6 months. All the biochemical markers including blood and urinary tests, hepatic and renal function, calcium, phosphorus and alkaline phosphatase etc. maintained within normal range before and after treatment. Radiological evaluation found 3 recurrent fractures of vertebral bodies, no serious adverse effects were found during the treatment. Conclusion Alendronate can effectively treat severe osteoporosis in elderly female, increase bone mass, relieve skeletal pains without serious adverse reactions in a short time, but the therapeutic effects and side effects of long-term therapy remained to be observed.

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备注/Memo

备注/Memo:
基金项目：河北省自然科学基金（C2011401025）
更新日期/Last Update: 2017-04-01