[1]董仁卫　郭琪　王家仲　王连成.老年人群肌力水平与心血管疾病 三大危险因素的相关性研究[J].中华老年骨科与康复电子杂志,2015,(02):29-34.[doi:10.3877/cma.j.issn.2096-0263.2015.02.006]
　Dong Renwei,Guo Qi,Wang Jiazhong,et al.The association between muscle strength level and three major risk factors of cardiovascular disease in elderly population[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2015,(02):29-34.[doi:10.3877/cma.j.issn.2096-0263.2015.02.006]
点击复制

老年人群肌力水平与心血管疾病 三大危险因素的相关性研究()
分享到：

中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2015年02期
页码:
29-34
栏目:
康复医学
出版日期:
2015-11-05

文章信息/Info

Title:
The association between muscle strength level and three major risk factors of cardiovascular disease in elderly population
作者:
董仁卫　郭琪　王家仲　王连成
天津医科大学康复与运动医学系；天津市天津医院康复科
Author(s):
Dong Renwei;  Guo Qi;  Wang Jiazhong;  Wang Liancheng
Department of Rehabilitation and Sports Medicine, Tianjin Medical University; Department of Rehabilitation Medicine, Tianjin Hospital,
关键词:
心血管疾病; 　危险因素; 　老年人; 　肌力
Keywords:
Cardiovascular diseases; 　 Risk factors;  　Aged;  　Muscle strength
DOI:
10.3877/cma.j.issn.2096-0263.2015.02.006
摘要:
目的　探究老年人群肌力水平与心血管疾病（cardiovascular disease，CVD）三大危 险因素患病之间的关系，并确定预测老年人群CVD 三大危险因素患病的肌力截断点，评价其临床意 义。方法　选取2014 年10 月至2015 年8 月天津市汉沽区茶店镇参加体检且符合纳入及排除标准的 受试对象1 140 例，采用调查问卷方式收集受试者的体格检查、生化、人口统计学特征、生活方式 和肌力水平等相关指标。肌力水平采用握力与体重比表示。受试者患有以下3 种疾病中的1 种及以 上者即定义为具备CVD 危险因素：糖尿病、高血压及高血脂。根据握力与体重比结果绘制ROC 曲 线，计算最佳肌力截断点，并应用Logistic 回归模型计算优势比（OR）和95% 可信区间（CI）分析 该肌力截断点对于CVD 危险因素患病的预测价值。结果　受试人群中CVD 三大危险因素至少1 种 的患病率分别为62.80% 和72.90%，肌力水平与CVD 三大危险因素的患病密切相关，肌力水平降低， CVD 三大危险因素患病率显著增高，这在老年女性中更显著。ROC 曲线结果显示，用于预测CVD 三大危险因素中至少1 种的男女性肌力水平最佳截断点分别为0.54 和0.34。Logistic 回归分析发现， 在调整年龄、BMI、吸烟、饮酒、运动锻炼、疾病史等混杂因素后，与高于肌力截断点的老年人群 相比，低于肌力截断点的老年人群CVD 三大危险因素至少1 种的患病风险OR 值分别为1.95（1.25， 3.06）和1.93（1.25，2.98）。结论　老年人群肌力水平下降可显著增加CVD 三大危险因素的患病率， 肌力截断点可一定程度上预测CVD 的患病风险，可为临床上老年人群肌肉力量训练进行量化管理提 供借鉴意义。
Abstract:
　Objective　To identify a threshold of muscle strength associated with three major cardiovascular disease (CVD) risk factors in elderly population and derive potential relationship between them. Methods　1 140 cases who participate in the medical test between October 2014 and August 2015 in Chadian Town, Hangu area of Tianjin, China were recruited. Questionnaires were used to collect information including physical examination, biochemical indicators, demographics, lifestyle, muscle strength level. Body muscle strength was calculated as a measure of one-repetition maximum hand-grip strength to body weight ratio. Inclusion criteria: elderly patients with any of three cardiovascular disease risk factors: diabetes mellitus, hypertension or hyperlipidemia. We created receiver operating curves to determine the optimal muscle strength cut points, with the presence of CVD risk factors as outcome variable. Logistic regression analyses were conducted to estimate the odds ratio (OR) and 95% confidence interval (CI) of CVD risk factors associated with recommended cut points of muscle strength. Results The prevalence of at least one three major CVD risk factor was 62.8% for men and 73.9% for women. Low muscle strength was associated with an increased likelihood of three major CVD risk factors in elderly, particularly among women. The best cut points of hand-grip strength/weight ratio for predicting at least one of the three major CVD risk factor were 0.54 for male and 0.34 for female, respectively. The adjusted OR of at least one of the three major CVD risk factor for those with low muscle strength was 1.95 for male and 1.93 for female, after adjustment for confounders such as age, smoking, drinking, BMI, physical activity and chronic conditions. Conclusion　In elderly population, threshold of muscle strength loss is significantly associated with the presence of any the three major CVD risk factors-HTN, DM, or hyperlipidemia. Measures of muscle strength may help predict elderly under high risk of chronic cardiometabolic diseases, and can provide reference for muscle strength training management in elderly population.

参考文献/References:

1 Auyeung TW, Lee SW, Leung J, et al. Age-associated decline of muscle mass, grip strength and gait speed: a 4-year longitudinal study of 3018 community-dwelling older Chinese [J]. Geriatr Gerontol Int, 2014, 14(Suppl 1): 76-84. 2 Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People [J]. Age Ageing, 2010, 39(4): 412-423. 3 Artero EG, Lee DC, Ruiz JR, et al. A prospective study of muscular strength and all-cause mortality in men with hypertension [J]. J Am Coll Cardiol, 2011, 57(18): 1831-1837. 4 Artero EG, Lee DC, Lavie CJ, et al. Effects of muscular strength on cardiovascular risk factors and prognosis [J]. J Cardiopulm Rehabil Prev, 2012, 32(6): 351-358. 5 Gr?ntved A, Pan A, Mekary RA, et al. Muscle-strengthening and conditioning activities and risk of type 2 diabetes: a prospective study in two cohorts of US women [J]. PLoS Med, 2014, 11(1): e1001587. 6 Expert Committee on the Diagnosis, Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus [J]. Diabetes Care, 1997, 20(7): 1183-1197. 7 Ito H, Nakasuga K, Ohshima A, et al. Detection of cardiovascular risk factors by indices of obesity obtained from anthropometry and dualenergy X-ray absorptiometry in Japanese individuals [J]. Int J Obes Relat Metab Disord, 2003, 27(2): 232-237. 8 Kim CH, Park HS, Park M, et al. Optimal cutoffs of percentage body fat for predicting obesity-related cardiovascular disease risk factors in Korean adults [J]. Am J Clin Nutr, 2011, 94(1): 34-39. 9 Maslow AL, Sui X, Colabianchi N, et al. Muscular strength and incident hypertension in normotensive and prehypertensive men [J]. Med Sci Sports Exerc, 2010, 42(2): 288-295. 10 Sénéchal M, Mcgavock JM, Church TS, et al. Cut points of muscle strength associated with metabolic syndrome in men [J]. Med Sci Sports Exerc, 2014, 46(8): 1475-1481. 11 冯香梅, 王国庆, 陈瑛, 等. 血清肿瘤标志物在肺癌诊断中的应用 价值 [J]. 中国肿瘤临床, 2010, 37(6): 331-334. 12 Sayer AA, Syddall HE, Dennison EM, et al. Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study [J]. QJM, 2007, 100(11): 707-713. 13 Lee SW, Youm Y, Lee WJ, et al. Appendicular skeletal muscle mass and insulin resistance in an elderly korean population: the korean social Life, health and aging project-health examination cohort [J]. Diabetes Metab J, 2015, 39(1): 37-45.

相似文献/References:

[1]吕厚辰,唐佩福.老年髋部骨折患者死亡风险评价[J].中华老年骨科与康复电子杂志,2016,(02):109.[doi:10.3877/cma.j.issn.2096-0263.2016.02.009]
　Lyu Houchen,Tang Peifu..Advancement of mortality prediction of aged hip fracture patients[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2016,(02):109.[doi:10.3877/cma.j.issn.2096-0263.2016.02.009]
[2]常晓,张保中,翁习生,等.高龄髋部骨折术后院内死亡的危险因素分析[J].中华老年骨科与康复电子杂志,2017,(01):43.[doi:10.3877/cma.j.issn.2096-0263.2017.01.009]
　Chang Xiao,ZhangBaozhong,WengXisheng,et al.Risk factor analysis for postoperative mortality in hospital of geriatric hip fracture patients[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2017,(02):43.[doi:10.3877/cma.j.issn.2096-0263.2017.01.009]
[3]李筱轶,秦瑾,张虎波,等.开放性骨折术后伤口感染的危险因素分析[J].中华老年骨科与康复电子杂志,2017,(02):85.[doi:10.3877/cma.j.issn.2096-0263.2017.02.004]
　Li Xiaoyi,Qin Jin,Zhang Hubo,et al.Risk analysis of surgical site infection in open fractures[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2017,(02):85.[doi:10.3877/cma.j.issn.2096-0263.2017.02.004]
[4]杨雄刚,胡永成,赵立明.老年骨科患者血栓预防的研究现状[J].中华老年骨科与康复电子杂志,2018,(02):65.[doi:10.3877/cma.j.issn.2096-0263.2018.02.001]
　Yang Xionggang,Hu Yongcheng,Zhao Liming.The thromboprophylaxis in geriatric orthopedics patients[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(02):65.[doi:10.3877/cma.j.issn.2096-0263.2018.02.001]
[5]鲁攀攀,马彬彬,李荥娟,等.老年髋部骨折患者术前营养不良的危险因素分析[J].中华老年骨科与康复电子杂志,2018,(03):145.[doi:10.3877/cma.j.issn.2096-0263.2018.03.005]
　Lu Panpan,Ma Binbin,Li Yingjuan,et al.Risk factors analysis for preoperative malnutrition of elderly hip fracture patients[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(02):145.[doi:10.3877/cma.j.issn.2096-0263.2018.03.005]
[6]张宇 秦晓东 许艺荠 谢文俊 胡军.老年股骨转子间骨折术后1年死亡率及危险因素分析[J].中华老年骨科与康复电子杂志,2018,(05):277.
　Zhang Yu,Qin Xiaodong,Xu Yiqi,et al.Risk factors related to mortality at one year after surgery for intertrochanteric fracture in the elderly[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(02):277.
[7]吴云军,王华军,郑小飞.肩袖修补术后再撕裂危险因素的研究进展[J].中华老年骨科与康复电子杂志,2019,(06):359.[doi:10.3877/cma.j.issn.2096-0263.2019.06.010]
　Wu Yun jun,Wang Huajun,Zheng Xiaofei..Research Progress on risk factors of retear after rotator cuff repair[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2019,(02):359.[doi:10.3877/cma.j.issn.2096-0263.2019.06.010]
[8]刘大伟,牛帅.老年粗隆间骨折后发生下肢深静脉血栓的多因素分析[J].中华老年骨科与康复电子杂志,2020,(03):128.[doi:10.3877/cma.j.issn.2096-0263.2020.03.002]
　Liu Dawei,Niu Shuai.Multifactor analysis of risk factors associated with deep venous thrombosis (DVT) in lower extremity after intertrochanteric fractures in the elderly[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2020,(02):128.[doi:10.3877/cma.j.issn.2096-0263.2020.03.002]
[9]段小静,韩超,陈洪.骨科I类（清洁）切口早期感染相关危险因素的前瞻性研究[J].中华老年骨科与康复电子杂志,2020,(04):197.[doi:10.3877/cma.j.issn.2096-0263.2020.04.003]
　Duan Xiaojing,Han Chao,Chen Hong..Prospective study of risk factors analysis about orthopaedic sterile incision with early infection[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2020,(02):197.[doi:10.3877/cma.j.issn.2096-0263.2020.04.003]
[10]张弢,俞光荣,朱燕宾,等.2015至2019年河北医科大学第三医院老年踝关节骨折的流行病学特征分析[J].中华老年骨科与康复电子杂志,2021,(01):4.[doi:10.3877/cma.j.issn.2096-0263.2021.01.002]
　Zhang Tao,Yu Guangrong,Zhu Yanbin,et al.A single center analysis for the epidemiological characteristics of eldly ankle fractures from Third Hospital of Hebei Medical University from 2015 to 2019[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2021,(02):4.[doi:10.3877/cma.j.issn.2096-0263.2021.01.002]

备注/Memo

备注/Memo:
国家自然科学基金面上项目（81372118）
更新日期/Last Update: 2015-12-30