[1]孙效棠,王万明,王辉,等.恶性肿瘤患者髋部骨折围术期血栓事件的对照研究[J].中华老年骨科与康复电子杂志,2018,(02):92-97.[doi:10.3877/cma.j.issn.2096-0263.2018.02.006]
　Sun Xiaotang,Wang Wanming,Wang Hui,et al.Comparative study of thrombotic events in hip fractures with/without therioma[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(02):92-97.[doi:10.3877/cma.j.issn.2096-0263.2018.02.006]
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恶性肿瘤患者髋部骨折围术期血栓事件的对照研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2018年02期
页码:
92-97
栏目:
深静脉血栓
出版日期:
2018-03-31

文章信息/Info

Title:
Comparative study of thrombotic events in hip fractures with/without therioma
作者:
孙效棠; 王万明; 王辉; 吕琦; 张志宏
350025 福州总医院骨二科
Author(s):
Sun Xiaotang;  Wang Wanming;  Wang Hui;  Lyu Qi;  Zhang Zhihong.
Department of orthopedics and traumatology, Fuzhou General Hospital, Fuzhou 350025, China
关键词:
髋骨折;  血栓形成;  肺栓塞;  恶性肿瘤
Keywords:
Hip fractures;  Thrombosis;  Pulmonary embolism;  Therioma
DOI:
10.3877/cma.j.issn.2096-0263.2018.02.006
文献标志码:
A
摘要:
目的 探讨恶性肿瘤患者髋部骨折围术期发生血栓相关事件的风险。方法 采用回顾性对照研究的方法，收集2011年6月至2017年6月6年福州总医院收治的患有恶性肿瘤同时发生髋部骨折的患者资料作为研究组（肿瘤组），将同期发生的髋部骨折的非恶性肿瘤患者（一般骨折组）按照以下指标和权重与肿瘤组进行配对：（1）抗凝/抗血小板药物的使用；（2）基础疾病；（3）体重指数；（4）性别；（5）年龄，以增强两组间可比性。配对后采用Wilcoxon秩检验对比分析两组Caprini评分和术后血栓事件的累计分值。结果 6年间共筛查出患有恶性肿瘤的髋部骨折患者31例，因各类原因有22例进入肿瘤组。回顾筛查出非恶性肿瘤的髋部骨折患者1 020例，按照上述指标和权重筛选出22例作为一般骨折组与肿瘤组进行配对。两组Caprini评分肿瘤组明显高于一般骨折组（t=30.702，P=0.003）。肿瘤组术后DVT新发率为36.4%（8/22），术后PE发生率为22.8%（5/22），其中3名患者死亡。一般骨折组术后新发DVT为4.5%（1/22），无PE发生。VTE事件发生严重程度两组间有显著差异（t=50.211，P=0.012）。结论 恶性肿瘤患者髋部骨折围术期血栓事件的发生率明显高于一般的髋部骨折患者并且更为严重。
Abstract:
Objective To evaluate the risks of venous thrombosis events for the hip fracture patients with therioma. Methods A retrospective review and paired comparison was applied in this study, patients with hip fracture were retrieved between June 2011 through June 2017. Patients with hip fracture and therioma were included into the experimental group (therioma group) and patients with hip fracture but no therioma were included into fracture group and were matched with therioma group according to the following parameters and weight: (1) anticoagulant/antiplatelet medications; (2) underlying conditions; (3) body mass index; (4) gender; (5) age, aiming to increase the strength of comparison. Caprini score and accumulation score of venous thrombosis events after surgery were compared using Wilcoxon rank test. Results Thirty-one hip fractures with therioma were retrieved during 6 years, and 22 of them were qualified as therioma group. One thousand and twenty cases with hip fractures but without therioma were also retrieved, and 22 of them were selected and matched with the therioma group according to the above mentioned parameters and weight. These 22 cases were defined as the fracture group. As for the Caprini score, the therioma group was statistically higher than the fracture group (t=30.702, P=0.003). Incidence of DVT after surgery in the therioma group was 8/22 (36.4%) and incidence of PE was 5/22 (22.8%), 3 died. Incidence of DVT was 1/22 (4.5%) and no PE occurred in the fracture group. Altogether, incidence of VTE of two groups was statistically different (t=50.211, P=0.012). Conclusion Patients with hip fracture and therioma has significantly higher incidence of VTE and severity than those without therioma.

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备注/Memo

备注/Memo:
基金项目：南京军区面上项目（15MS132）
更新日期/Last Update: 2018-03-27