参考文献/References:
1 Kitagawa K, Matsumoto M, Tagaya M, et al. ‘Ischemic tolerance’ phenomenon found in the brain [J]. Brain Res, 1990, 528(1): 21-24.
2 Schmidt A, Wellmann J, Schilling M, et al. Meta-analysis of the efficacy of different training strategies in animal models of ischemic stroke [J]. Stroke, 2014, 45(1): 239-247.
3 Middleton LE, Corbett D, Brooks D, et al. Physical activity in the prevention of ischemic stroke and improvement of outcomes: a narrative review [J]. Neurosci Biobehav Rev, 2013, 37(2): 133-137.
4 Lee CD, Folsom AR, Blair SN. Physical activity and stroke risk: a meta-analysis [J]. Stroke, 2003, 34(10): 2475-2481.
5 Alevizos A, Lentzas J, Kokkoris S, et al. Physical activity and stroke risk [J]. Int J Clin Pract, 2005, 59(8): 922-930.
6 Vinereanu D. Risk factors for atherosclerotic disease: present and future [J]. Herz, 2006, 31(Suppl 3): 5-24.
7 Chrysohoou Ch, Pitsavos Ch, Kokkinos P, et al. The role of physical activity in the prevention of stroke [J]. Cent Eur J Public Health, 2005, 13(3): 132-136.
8 Evenson KR, Rosamond WD, Cai J, et al. Physical activity and ischemic stroke risk. The atherosclerosis risk in communities study [J]. Stroke, 1999, 30(7): 1333-1339.
9 魏翠兰, 袁琼嘉. 运动预处理对力竭运动后大脑皮质微结构与自由基代谢的影响 [J]. 山东体育学院学报, 2012, 28(5): 55-61.
10 沈志祥, 孟萌, 刘翠鲜, 等. 跑台运动训练对Ⅱ型糖尿病大鼠骨生物力学性能的影响 [J]. 中华物理医学与康复杂志, 2013, 35(10): 753-756.
11 Reiss JI, Dishman RK, Boyd HE, et al. Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat: possible role of galanin [J].Brain Res, 2009, 1266: 54-63.
12 Dornbos D, Zwagerman N, Guo M, et al. Preischemic exercise reduces brain damage by ameliorating metabolic disorder in ischemia/reperfusion injury [J]. J Neurosci Res, 2013, 91(6): 818-827.
13 孙竹梅, 赵雅宁, 李建民, 等. 不同强度运动对脑缺血再灌注大鼠学习能力及氧自由基代谢的影响 [J]. 中国康复理论与实践, 2015, 21 (1): 26-30.
14 Hu X, Zheng H, Yan T, et al. Physical exercise induces expression of CD31 and facilitates neural function recovery in rats with focal cerebral infarction [J]. Neurol Res, 2010, 32(4): 397-402.
15 Zhang F, Wu Y, Jia J, et al. Pre-Ischemic treadmill training induces tolerance to brain ischemia: involvement of glutamate and ERK1/2 [J]. Molecules, 2010, 15(8): 5246-5257.
16 Wang RY, Yang YR, Yu SM. Protective effects of treadmill training on infarction in rats [J]. Brain Res, 2001, 922(1): 140-143.
17 Jia J, Hu YS, Wu Y, et al. Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia [J]. Life Sci, 2009, 84(15/16): 505-511.
18 Liebelt B, Papapetrou P, Ali A, et al. Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2 [J]. Neuroscience, 2010, 166(4): 1091-1100.
19 Memezawa H, Smith ML, Siesjö BK. Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats [J]. Stroke, 1992, 23(4): 552-559.
20 Li Y, Powers C, Jiang N, et al. Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat [J]. J Neurol Sci, 1998, 156(2): 119-132.
21 Chen J, Zhu RL, Nakayama M, et al. Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia [J]. J Neurochem, 1996, 67(1): 64-71.
22 Ferrer I, Friguls B, Dalfó E, et al. Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat [J]. Neuropathol Appl Neurobiol, 2003, 29(5): 472-481.
23 Chen J, Graham SH, Zhu RL, et al. Stress proteins and tolerance to focal cerebral ischemia [J]. J Cereb Blood Flow Metab, 1996, 16(4): 566-577.
24 Giffard RG, Yenari MA. Many mechanisms for hsp70 protection from cerebral ischemia [J]. J Neurosurg Anesthesiol, 2004, 16(1): 53-61.
25 Ohtsuka K, Suzuki T. Roles of molecular chaperones in the nervous system [J]. Brain Res Bull, 2000, 53(2): 141-146.
26 Lee JE, Yenari MA, Sun GH, et al. Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions [J]. Exp Neurol, 2001, 170(1): 129-139.
27 Masada T, Hua Y, Xi G, et al. Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat [J]. J Cereb Blood Flow Metab, 2001, 21(1): 22-33.
28 Starnes JW, Choilawala AM, Taylor RP, et al. Myocardial heat shock protein 70 expression in young and old rats after identical exercise programs [J]. J Gerontol A Biol Sci Med Sci, 2005, 60(8): 963-969.
29 Li DY, Tao L, Liu H, et al. Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion [J]. Apoptosis, 2006, 11(6): 923-930.
30 Sawatzky DA, Willoughby DA, Colville-Nash PR, et al. The involvement of the apoptosis-modulating proteins ERK 1/2, Bcl-xL and Bax in the resolution of acute inflammation in vivo [J]. Am J Pathol, 2006, 168(1): 33-41.
31 Zhuang S, Schnellmann RG. A death-promoting role for extracellular signal-regulated kinase [J]. J Pharmacol Exp Ther, 2006, 319(3): 991-997.
32 Stoica BA, Movsesyan VA, Knoblach SM, et al. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins [J]. Mol Cell Neurosci, 2005, 29(3): 355-371.
33 王璐, 邓文骞, 袁琼嘉. 运动预处理对力竭运动诱导的大鼠大脑皮质细胞凋亡的影响 [J]. 中国运动医学杂志, 2012, 31(7): 602-606.
34 Chaudhry K, Rogers R, Guo M, et al. Matrix metalloproteinase-9 (MMP-9) expression and extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation in exercise-reduced neuronal apoptosis after stroke [J]. Neurosci Lett, 2010, 474(2): 109-114.
35 Correale J, Villa A. The neuroprotective role of inflammation in nervous system injuries [J]. J Neurol, 2004, 251(11): 1304-1316.
36 Stoll G, Jander S, Schroeter M. Inflammation and glial responses in ischemic brain lesions [J]. Prog Neurobiol, 1998, 56(2): 149-171.
37 Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke [J]. J Neuroimmunol, 2007, 184(1/2): 53-68.
38 Emsley HC, Hopkins SJ. Acute ischaemic stroke and infection: recent and emerging concepts [J]. Lancet Neurol, 2008, 7(4): 341-353.
39 Stenzel-Poore MP, Stevens SL, King JS, et al. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis [J]. Stroke, 2007, 38(2 Suppl): 680-685.
40 Blondeau N, Widmann C, Lazdunski M, et al. Activation of the nuclear factor-kappaB is a key event in brain tolerance [J]. J Neurosci, 2001, 21(13): 4668-4677.
41 Ohtsuki T, Ruetzler CA, Tasaki K, et al. Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons [J]. J Cereb Blood Flow Metab, 1996, 16(6): 1137-1142.
42 Cárdenas A, Moro MA, Leza JC, et al. Upregulation of TACE/Adam17 after ischemic preconditioning is involved in brain tolerance [J]. J Cereb Blood Flow Metab, 2002, 22(11): 1297-1302.
43 Liu J, Ginis I, Spatz M, et al. Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide [J]. Am J Physiol Cell Physiol, 2000, 278(1): C144-C153.
44 Ding YH, Young CN, Luan X, et al. Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion [J]. Acta Neuropathol, 2005, 109(3): 237-246.
45 Guo M, Lin V, Davis W, et al. Preischemic induction of TNF-alpha by physical exercise reduces blood-brain barrier dysfunction in stroke [J]. J Cereb Blood Flow Metab, 2008, 28(8): 1422-1430.
46 朱路文, 叶涛, 吴孝军, 等. 运动预处理对脑缺血再灌注大鼠血清炎症因子水平的影响 [J]. 中国康复理论与实践, 2015 (1): 22-25.
47 Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia [J]. Mol Neurobiol, 2003, 28(3): 229-244.
48 Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain [J]. Stroke, 1998, 29(10): 2189-2195.
49 Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia [J]. J Neurosci, 2001, 21(19): 7724-7732.
50 Hornebeck W, Lambert E, Petitfrère E, et al. Beneficial and detrimental influences of tissue inhibitor of metalloproteinase-1 (TIMP-1) in tumor progression [J]. Biochimie, 2005, 87(3/4): 377-383.
51 Guo M, Cox B, Mahale S, et al. Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke [J]. Neuroscience, 2008, 151(2): 340-351.
52 Kleffner I, Bungeroth M, Schiffbauer H, et al. The role of aquaporin-4 polymorphisms in the development of brain edema after middle cerebral artery occlusion [J]. Stroke, 2008, 39(4): 1333-1335.
53 Bullitt E, Rahman FN, Smith JK, et al. The effect of exercise on the cerebral vasculature of healthy aged subjects as visualized by Mr angiography [J]. AJNR Am J Neuroradiol, 2009, 30(10): 1857-1863.
54 Isaacs KR, Anderson BJ, Alcantara AA, et al. Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning [J]. J Cereb Blood Flow Metab, 1992, 12(1): 110-119.
55 Swain RA, Harris AB, Wiener EC, et al. Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat [J]. Neuroscience, 2003, 117(4): 1037-1046.
56 Ding Y, Li J, Luan X, et al. Exercise pre-conditioning reduces brain damage in ischemic rats that May be associated with regional angiogenesis and cellular overexpression of neurotrophin [J]. Neuroscience, 2004, 124(3): 583-591.
57 Ding YH, Li J, Yao WX, et al. Exercise preconditioning upregulates cerebral integrins and enhances cerebrovascular integrity in ischemic rats [J]. Acta Neuropathol, 2006, 112(1): 74-84.
58 Rhyu IJ, Bytheway JA, Kohler SJ, et al. Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys [J]. Neuroscience, 2010, 167(4): 1239-1248.
59 Zwagerman N, Sprague S, Davis MD, et al. Pre-ischemic exercise preserves cerebral blood flow during reperfusion in stroke [J]. Neurol Res, 2010, 32(5): 523-529.
60 Tang K, Xia FC, Wagner PD, et al. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle [J]. Respir Physiol Neurobiol, 2010, 170(1): 16-22.
61 Cotman CW, Berchtold NC, Christie LA. Exercise builds brain health: key roles of growth factor cascades and inflammation [J]. Trends Neurosci, 2007, 30(9): 464-472.
62 Aberg MA, Aberg ND, Hedbäcker H, et al. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus [J]. J Neurosci, 2000, 20(8): 2896-2903.
63 Cao L, Jiao X, Zuzga DS, et al. VEGF links hippocampal activity with neurogenesis, learning and memory [J]. Nat Genet, 2004, 36(8): 827-835.
64 Trejo JL, Carro E, Torres-Aleman I. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus [J]. J Neurosci, 2001, 21(5): 1628-1634.
65 Fabel K, Fabel K, Tam B, et al. VEGF is necessary for exercise-induced adult hippocampal neurogenesis [J]. Eur J Neurosci, 2003, 18(10): 2803-2812.
66 Opitz T, Grooms SY, Bennett MV, et al. Remodeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit composition in hippocampal neurons after global ischemia [J]. Proc Natl Acad Sci U S A, 2000, 97(24): 13360-13365.
67 Mitani A, Tanaka K. Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1 [J]. J Neurosci, 2003, 23(18): 7176-7182.
68 Jiang X, Tian F, Mearow K, et al. The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons [J]. J Neurochem, 2005, 94(3): 713-722.
69 Soriano FX, Papadia S, Hofmann F, et al. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability [J]. J Neurosci, 2006, 26(17): 4509-4518.
70 Sommer C, Roth SU, Kuhn R, et al. Metabotropic glutamate receptor subtypes are differentially expressed after transient cerebral ischemia without, during and after tolerance induction in the gerbil hippocampus [J]. Brain Res, 2000, 872(1/2): 172-180.
71 Zhang F, Jia J, Wu Y, et al. The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia [J]. Int J Mol Sci, 2010, 11(7): 2658-2669.
72 Wang X, Zhang M, Feng R, et al. Exercise pre?conditioning alleviates brain damage via excitatory amino acid transporter 2 and extracellular signal?regulated kinase 1/2 following ischemic stroke in rats [J]. Mol Med Rep, 2015, 11(2): 1523-1527.