负重关节与非负重关节软骨基因表达差异的初步研究-中华老年骨科与康复电子杂志

文章信息/Info

作者:: 王天瑞1; 于承浩1; 孙泽文1; 李金波2; 3; 赵海波1; 李天予1; 薛俊强4; 陈伟3; 5; 6; 张英泽3; 5; 6; 于腾波1; 266555 青岛大学附属医院骨科1；050017 石家庄，河北医科大学医学与健康研究院2；050051 石家庄，河北省骨科研究所3；266555 青岛大学附属医院康复医学科4；050051 石家庄，河北医科大学第三医院骨科5；050051 石家庄，国家卫生健康委骨科智能器材实验室6

Author(s):: Wang Tianrui1; Yu Chenghao1; Sun Zewen1; Li Jinbo2; 3; Zhao Haibo1; Li Tianyu1; Xue Junqiang4; Chen Wei3; 5; Zhang Yingze3; 5; 6; Yu Tengbo1; 1Department of Orthopaedic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266555, China; 2Institute of medicine and health, Hebei Medical University, Shi Jiazhuang 050051, China; 3Orthopaedic Institute of Hebei Province, Shijiazhuang 050051, China; 4Department of rehabilitation medicine, Affiliated Hospital of Qingdao University, Qingdao 266555, China; 5Department of Orthopaedics Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; 6NHC Key Laboratory of Intelligent Orthopeadic Equipment, Shijiazhuang 050051, China

Keywords:: Articular cartilage; Gene expression; Weight bearing; Non-weight bearing

摘要:: 关节软骨覆盖于关节表面，具有较好的润滑性能且富有弹性,在吸收负重载荷的过程中起到重要作用。本团队收集了新鲜尸体的膝、肩关节软骨并进行转录组测序，发现负重关节与非负重关节软骨之间的基因表达存在差异。

Abstract:: Articular cartilage is a layer of dense connective tissue that covers the surface of the joint. It has excellent lubricating properties and elasticity. It plays an important role in absorbing load distribution and alleviating joint shock. Our team collected the knee and shoulder articular cartilage of fresh cadavers and performed gene sequencing, and found that there were differences in the expression of articular cartilage in different parts.