[1]郑凯,于秀淳,徐明,等.老年软组织肉瘤临床特征及治疗方案的研究[J].中华老年骨科与康复电子杂志,2021,(06):352-358.[doi:10.3877/cma.j.issn.2096-0263.2021.06.006]
　Zheng Kai,Yu Xiuchun,Xu Ming,et al.Clinical features and treatment options of soft tissue sarcoma in the elderly[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2021,(06):352-358.[doi:10.3877/cma.j.issn.2096-0263.2021.06.006]
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老年软组织肉瘤临床特征及治疗方案的研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2021年06期
页码:
352-358
栏目:
骨肿瘤
出版日期:
2021-12-05

文章信息/Info

Title:
Clinical features and treatment options of soft tissue sarcoma in the elderly
作者:
郑凯; 于秀淳; 徐明; 崔浩诚; 陈倩
250031 中国人民解放军联勤保障部队第九六〇医院骨科
Author(s):
Zheng Kai;  Yu Xiuchun;  Xu Ming;  Cui Haocheng;  Chen Qian
Department of Orthopaedics, Department of orthopedics, The 960th Hospital of PLA joint logistics support force, Jinan 250031, China
关键词:
软组织肉瘤;  老年人;  临床特征;  治疗
Keywords:
Soft tissue sarcoma;  Aged;  Clinical features;  Treatment
DOI:
10.3877/cma.j.issn.2096-0263.2021.06.006
文献标志码:
A
摘要:
目的 分析老年软组织肉瘤患者的临床特征，探讨其治疗策略。方法 回顾性分析解放军第九六〇医院2010年1月至2020年12月间所有接受手术治疗的老年软组织肉瘤患者临床资料，按性别、年龄、肿瘤类型、发病部位、肿瘤最大径、手术次数、保肢情况、辅助治疗、复发及转移、无疾病生存时间、总生存时间分别进行统计，分析患者临床特征、研究其治疗方案。结果 66例患者中有63例（95.5%）老年软组织肉瘤患者纳入本研究，其中男38例（60.3%），女25例（39.7%），男女比例为1.52∶1。发病年龄为60～93岁，平均年龄（68.4±6.7）岁，未分化多形性肉瘤、脂肪肉瘤和纤维肉瘤是最常见的病理类型。发病部位：下肢40例、上肢12例、躯干11例。不同发病部位组间分析显示仅肿瘤最大径差异存在统计学意义（F=3.196，P=0.048）。52例肢体软组织肉瘤中43例保肢成功，辅助治疗率19.0%（12/63），复发及转移率46.0%（29/63）。中位无疾病生存时间和中位总生存时间均为87.5个月，随访3～108月，30例患者因肿瘤进展死亡，肢体软组织肉瘤保肢与截肢患者生存率差异无统计学意义（c2=3.724，P=0.054）。结论 老年软组织肉瘤患者具有病理级别高、肿瘤负荷大、预后较差的特点，保肢术是外科治疗的首选，积极的辅助治疗有助于获得更好的临床疗效。
Abstract:
Objective To analyze the clinical characteristics of elderly patients with soft tissue sarcoma and explore the treatment strategy. Methods From January 2010 to December 2020, the clinical data of all elderly patients with soft tissue sarcoma who received surgical treatment in PLA 960th Hospital were retrospectively analyzed. The patients’ gender, age, tumor type, site of disease, maximum diameter of tumor, limb salvage, adjuvant treatment, recurrence and metastasis, disease-free survival time and overall survival time, and the different sites of disease were analyzed. Statistical analysis was carried between different tumor location groups. All patients’ clinical characteristics and treatments were analyzed. Results Sixty-three elderly patients with soft tissue sarcoma were included in this study, including 38 males (60.3%) and 25 females (39.7%). The ratio of male to female was 1.52∶1. The age of onset ranged from 60 to 93 years (mean 68.4±6.7 years). Undifferentiated pleomorphic sarcoma, liposarcoma and fibrosarcoma were the most common pathological types. The location of the disease: 40 cases of lower limbs, 12 cases of upper limbs, 11 cases of trunk. There was significant difference only in the maximum diameter of the tumor (F=3.196, P=0.048). Of 52 cases of limb soft tissue sarcoma, 43 cases were successfully preserved. The adjuvant treatment rate was 19.0% (12/63), and the recurrence and metastasis rate was 46.0% (29/63). The median disease-free survival time and median overall survival time were 87.5 months. During the follow-up of 3-108 months, 30 patients died due to tumor progression. There was no significant difference in survival rate between limb salvage and amputation patients with limb soft tissue sarcoma (c2=3.724, P=0.054). Conclusion The elderly patients with soft tissue sarcoma have the characteristics of high pathological grade, high tumor load and poor prognosis. Limb salvage is the first choice for surgical treatment, and active adjuvant treatment is helpful to obtain better clinical efficacy.

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备注/Memo

备注/Memo:
基金项目：院长基金博士课题（2017BS03）
更新日期/Last Update: 2022-04-25