[1]廖江涛,宋振宇,徐浩,等.中老年女性血清总睾酮水平与骨关节炎发生风险的横断面研究[J].中华老年骨科与康复电子杂志,2025,(05):271-279.[doi:10.3877/cma.j.issn.2096-0263.2025.05.002]
　Liao Jiangtao,Song Zhenyu,Xu Hao,et al.Cross-sectional study on serum total testosterone levels and the risk of osteoarthritis in Middle-aged and Elderly Women[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2025,(05):271-279.[doi:10.3877/cma.j.issn.2096-0263.2025.05.002]
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中老年女性血清总睾酮水平与骨关节炎发生风险的横断面研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2025年05
页码:
271-279
栏目:
关节炎
出版日期:
2025-10-05

文章信息/Info

Title:
Cross-sectional study on serum total testosterone levels and the risk of osteoarthritis in Middle-aged and Elderly Women
作者:
廖江涛1; 宋振宇2; 徐浩1; 李翼1; 徐冬冬1; 于威1; 代志鹏3; 田洪涛1; 童伟1
430022 武汉，华中科技大学同济医学院附属协和医院骨科1；541000 桂林医学院附属第二医院2； 450003 郑州，河南省人民医院3
Author(s):
Liao Jiangtao1;  Song Zhenyu2;  Xu Hao1;  Li Yi1;  Xu Dongdong1;  Yu Wei1;  Dai Zhipeng3;  Tian Hongtao1;  Tong Wei1.
1Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 2The Second Affiliated Hospital of Guilin Medical University, Guilin 541000, China; 3Department of Orthopedics, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou 450003, China
关键词:
骨关节炎;  睾酮;  中老年女性;  横断面研究
Keywords:
Osteoarthritis;  Testosterone;  Middle-aged and older women;  Cross-sectional study
DOI:
10.3877/cma.j.issn.2096-0263.2025.05.002
文献标志码:
A
摘要:
目的 关于血清总睾酮（TST）水平与骨关节炎（OA）间的关系尚不清楚，本研究旨在调查血清总睾酮水平与中老年女性OA发生风险间的关联。方法 采用横断面研究设计，纳入美国国家健康与营养调查（NHANES）2013-2016周期中1 627名50岁及以上女性数据。暴露变量为血清总睾酮水平，结局变量为OA。结果　多变量逻辑回归分析显示，血清总睾酮水平较高与50岁及以上女性OA发生风险显著降低相关。具体而言，血清总睾酮水平每升高20个单位，OA发生风险降低27.2%（OR=0.728；95% CI：0.566，0.936；P=0.0169）。平滑曲线拟合二者间的关联呈线性关系。交互作用检验表明，年龄、BMI、高血压、糖尿病、腰围、血清总胆固醇水平、雌二醇水平及性激素结合球蛋白水平水平均未显著改变睾酮与OA间的关联性。结论　在美国50岁及以上的女性中，较高的血清睾酮水平与较低的OA发生风险相关，本研究为血清总睾酮水平与OA间的关系提供了新的见解和证据。
Abstract:
Objective　The relationship between serum total testosterone levels and osteoarthritis (OA) remains controversial. This study aimed to investigate the association between serum total testosterone levels and the risk of OA in middle-aged and older women. Methods　 A cross-sectional study design was employed, including data from 1,627 women aged 50 and older from the 2013-2016 cycles of the National Health and Nutrition Examination Survey (NHANES) in the United States. The exposure variable was serum total testosterone levels, and the outcome variable was OA. Results　The multivariable logistic regression analysis revealed a significant association between higher serum testosterone levels and a reduced risk of OA in women over 50 in the United States. Specifically, for every 20-unit increase in serum testosterone levels, the risk of OA decreased by 27.2% [OR =0.728; 95% CI: 0.566, 0.936; P=0.0169]. The smooth curve fitting demonstrated a linear relationship between the two variables. Interaction tests showed that factors such as age, BMI, hypertension, diabetes, waist circumference, serum total cholesterol levels, estradiol levels, and SHBG levels did not significantly influence the relationship between serum testosterone levels and OA. Conclusions　In women aged 50 and older in the United States, higher serum testosterone levels are associated with a lower risk of OA. This study provides new insights and evidence into the relationship between serum testosterone levels and OA.

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备注/Memo

备注/Memo:
基金项目：湖北省科学技术厅项目（2023BCB089）；国家自然科学基金项目（82372465）；国家自然科学基金项目（82202762）
更新日期/Last Update: 2026-05-18