[1]郝亚逢,李远,王治乾,等.左西孟旦治疗围手术期老年髋部骨折合并心衰患者的疗效研究[J].中华老年骨科与康复电子杂志,2018,(01):29-32.[doi:10.3877/cma.j.issn.2096-0263.2018.01.007]
　Hao Yafeng,Li Yuan,Wang Zhiqian,et al.Effectivness study of Leosimendan in the treatment of perioperative in elderly hip fracture with heart failure[J].Chin J Geriatr Orthop Rehabil(Electronic Edition),2018,(01):29-32.[doi:10.3877/cma.j.issn.2096-0263.2018.01.007]
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左西孟旦治疗围手术期老年髋部骨折合并心衰患者的疗效研究()
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中华老年骨科与康复电子杂志[ISSN:1674-3911/CN:11-9292/R]

卷:
期数:
2018年01期
页码:
29-32
栏目:
髋部骨折合并心力衰竭
出版日期:
2018-01-31

文章信息/Info

Title:
Effectivness study of Leosimendan in the treatment of perioperative in elderly hip fracture with heart failure
作者:
郝亚逢1; 李远2; 王治乾3; 纪文永4; 王旭东5
056002 邯郸市第一医院心内二科1；4050011 石家庄市第四医院急诊科2；050051 石家庄，河北医科大学第三医院老年骨科3；056002 邯郸，成安县中医院心内科4；056002 邯郸市第一医院骨科5
Author(s):
Hao Yafeng1;  Li Yuan2;  Wang Zhiqian3;  Ji Wenyong4;  Wang Xudong5
1Department of Cardiology, the First Hospital of Handan, Handan 056002, China, 2Department of Internal Medicine, the Fourth Hospital of Shijiazhuang, Shijiazhuang 050011, China; 3Department of Cardiology, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; 4Department of Cardiology, the Chinese Hospital of Chengan, Handan 056002, China; 5Department of Orthopedics, the First Hospital of Handan, Handan 056002, China
关键词:
髋骨折;  老年人;  左西孟旦;  心力衰竭
Keywords:
Hip fractures;  Aged;  Simendan;  Heart failure
DOI:
10.3877/cma.j.issn.2096-0263.2018.01.007
文献标志码:
A
摘要:
目的 探讨左西孟旦治疗围手术期老年髋部骨折合并心力衰竭患者的疗效。方法 回顾性分析2013年1月至2016年12月于邯郸市第一医院接受手术治疗且符合纳入标准的老年髋部骨折合并心力衰竭的患者64例（股骨颈骨折30例，股骨转子间骨折34例），根据围手术期是否使用左西孟旦，分为左西孟旦组和对照组，其中左西孟旦组32例，对照组32例，比较应用左西孟旦前、术后24 h、7 d后左室射血分数（LVEF）、心输出量（CO）、心脏指数（CI）、B型钠尿肽水平（BNP），对左西孟旦的疗效进行评价。结果 左西孟旦组术后24 h、术后7 d LVEF、CI、CO均明显高于同时间对照组（LVEF：t=2.428，t=3.150；CI：t=3.349，t=3.777；CO：t=2.615，t=2.620，均P＜0.05），左西孟旦组术后24 h、术后7 d BNP水平明显低于对照组，差异有统计学意义（t=2.989，t=2.693，P＜0.05）。结论 左西孟旦可改善老年髋部骨折合并心力衰竭患者围手术期的血流动力学指标，改善心脏功能及预后。
Abstract:
Objective To study the effect of levosimendan in the treatment of elderly heart failure patients underwent urgent hip fracture repairment. Methods A retrospective analysis was performed in the First Hospital of Handan from January 2013 to December 2016, including 64 (30 femoral neck fracture, 34 intertrochanteric fracture) elderly hip fractures conforming to inclusion criteria. Patients were divided into levosimendan group and control group according to the application of levosimendan, the levosimendan group had 32 cases same as the control group. The left ventricular ejection fraction (LVEF), b-type natriuretic peptide (BNP) and cardiac output (CO), cardiac index (CI) before application of levosimendanat 24 h and 7 d after surgery were compared to evaluate the curative effect of levosimendan. Results LVEF, CO, CI at 24 h and 7 d after syrgery in Leosimendan group were significantly higher than control group (LVEF: t=2.428, t=3.150; CI: t=3.349, t=3.777; CO: t=2.615, t=2.620, P<0.05), BNP levels at 24 h and 7 d after surgery in leosimendan group was significantly lower than the control group, with statistical significance (t=2.989, t=2.693, P<0.05). Conclusion Levosimendan can be used to improve heart function and prognosis of elderly hip fracture with heart failure by regulating perioperative hemodynamic index.

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备注/Memo

备注/Memo:
基金项目：河北省医学科学重点研究课题（20110420）；邯郸市科学技术研究与发展计划项目（1423108063-6）
更新日期/Last Update: 2018-01-31